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Int J Mol Sci：生物活性玻璃涂层可更好的促进植入物的骨整合

2019-07-24 不详 网络

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实现假体植体的稳定骨整合是现代整形外科手术的巨大挑战之一。髋关节假体的陶瓷髋臼杯的固定通常使用具有穿透宿主骨盆骨的螺钉或钉的金属壳来实现。在植体表面上沉积生物活性涂层以与骨接触可能是促进更“生理”骨整合的有效策略。在这项工作中，生物活性玻璃多孔涂层是通过两种不同的方法在氧化铝/氧化锆复合材料植入物的顶部制造的，即海绵复制和激光熔覆。涂覆的样品在Kokubo的模拟体液（SBF）中进行浸泡研究以评估体

实现假体植体的稳定骨整合是现代整形外科手术的巨大挑战之一。髋关节假体的陶瓷髋臼杯的固定通常使用具有穿透宿主骨盆骨的螺钉或钉的金属壳来实现。在植体表面上沉积生物活性涂层以与骨接触可能是促进更“生理”骨整合的有效策略。

在这项工作中，生物活性玻璃多孔涂层是通过两种不同的方法在氧化铝/氧化锆复合材料植入物的顶部制造的，即海绵复制和激光熔覆。涂覆的样品在Kokubo的模拟体液（SBF）中进行浸泡研究以评估体外生物活性，并且发现其具有优异的羟基磷灰石形成能力，这是允许与骨结合的关键。使用间充质干细胞和成骨细胞样细胞的生物学试验揭示了两种类型材料的良好生物相容性。此外，海绵复制的涂层在10天时诱导了更高水平的矿化。

总体而言，这些结果表明值得对这些材料进行进一步的研究。

原始出处：

Baino F, Minguella-Canela J, et al., In Vitro Assessment of Bioactive Glass Coatings on Alumina/Zirconia Composite Implants for Potential Use in Prosthetic Applications. Int J Mol Sci. 2019 Feb 8;20(3). pii: E722. doi: 10.3390/ijms20030722.

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    2020-05-06 fyxzlh

    #生物活性玻璃#

    0

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    2019-07-27 yjs木玉

    好好好好好好

    0

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    2019-07-26 linagood

    #植入物#

    0

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    2019-07-26 jiyangfei

    #植入#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2005193, encodeId=074c200519385, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Wed May 06 02:10:00 CST 2020, time=2020-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370327, encodeId=0af23e0327d2, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Jul 27 06:13:03 CST 2019, time=2019-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490917, encodeId=1eee149091e93, content=<a href='/topic/show?id=fb916268636' target=_blank style='color:#2F92EE;'>#植入物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62686, encryptionId=fb916268636, topicName=植入物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38628846382, createdName=linagood, createdTime=Fri Jul 26 14:10:00 CST 2019, time=2019-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520605, encodeId=d93a152060575, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Fri Jul 26 14:10:00 CST 2019, time=2019-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521784, encodeId=3a121521e8456, content=<a href='/topic/show?id=0b8f101e026a' target=_blank style='color:#2F92EE;'>#骨整合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101702, encryptionId=0b8f101e026a, topicName=骨整合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=03f111392267, createdName=bnurmamat, createdTime=Fri Jul 26 14:10:00 CST 2019, time=2019-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370227, encodeId=71b83e022711, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu Jul 25 06:49:28 CST 2019, time=2019-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370226, encodeId=cd583e022607, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Jul 25 05:41:07 CST 2019, time=2019-07-25, status=1, ipAttribution=)]
    2019-07-26 bnurmamat

    #骨整合#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2005193, encodeId=074c200519385, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Wed May 06 02:10:00 CST 2020, time=2020-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370327, encodeId=0af23e0327d2, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Jul 27 06:13:03 CST 2019, time=2019-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490917, encodeId=1eee149091e93, content=<a href='/topic/show?id=fb916268636' target=_blank style='color:#2F92EE;'>#植入物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62686, encryptionId=fb916268636, topicName=植入物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38628846382, createdName=linagood, createdTime=Fri Jul 26 14:10:00 CST 2019, time=2019-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520605, encodeId=d93a152060575, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Fri Jul 26 14:10:00 CST 2019, time=2019-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521784, encodeId=3a121521e8456, content=<a href='/topic/show?id=0b8f101e026a' target=_blank style='color:#2F92EE;'>#骨整合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101702, encryptionId=0b8f101e026a, topicName=骨整合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=03f111392267, createdName=bnurmamat, createdTime=Fri Jul 26 14:10:00 CST 2019, time=2019-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370227, encodeId=71b83e022711, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu Jul 25 06:49:28 CST 2019, time=2019-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370226, encodeId=cd583e022607, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Jul 25 05:41:07 CST 2019, time=2019-07-25, status=1, ipAttribution=)]
    2019-07-25 深海的鱼

    学习学习学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2005193, encodeId=074c200519385, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Wed May 06 02:10:00 CST 2020, time=2020-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370327, encodeId=0af23e0327d2, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Sat Jul 27 06:13:03 CST 2019, time=2019-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490917, encodeId=1eee149091e93, content=<a href='/topic/show?id=fb916268636' target=_blank style='color:#2F92EE;'>#植入物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62686, encryptionId=fb916268636, topicName=植入物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=38628846382, createdName=linagood, createdTime=Fri Jul 26 14:10:00 CST 2019, time=2019-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520605, encodeId=d93a152060575, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Fri Jul 26 14:10:00 CST 2019, time=2019-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521784, encodeId=3a121521e8456, content=<a href='/topic/show?id=0b8f101e026a' target=_blank style='color:#2F92EE;'>#骨整合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101702, encryptionId=0b8f101e026a, topicName=骨整合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=03f111392267, createdName=bnurmamat, createdTime=Fri Jul 26 14:10:00 CST 2019, time=2019-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370227, encodeId=71b83e022711, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Thu Jul 25 06:49:28 CST 2019, time=2019-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370226, encodeId=cd583e022607, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Jul 25 05:41:07 CST 2019, time=2019-07-25, status=1, ipAttribution=)]
    2019-07-25 1e1c07bdm01(暂无匿称)

    好

    0