Crit Care Med:预测急性低氧性呼吸衰竭患者进行气管插管的实用指标!

2017-11-05 MedSci MedSci原创

在急性低氧性呼吸衰竭患者中,无创通气和高流量鼻导管吸氧是目前常规氧疗的替代策略。临床上,上述患者常常具有气管内插管的风险,早期预测呼吸衰竭可以帮助临床医生早日做出决定。近期,一项发表在杂志Crit Care Med上的研究旨在确定与使用不同的非侵入性氧合技术治疗急性低氧性呼吸衰竭患者插管的相关因素。此项研究为事后分析的随机临床试验。受试患者为呼吸频率大于25次/分钟且PaO2/FIO2比率小于或等

在急性低氧性呼吸衰竭患者中,无创通气和高流量鼻导管吸氧是目前常规氧疗的替代策略。临床上,上述患者常常具有气管内插管的风险,早期预测呼吸衰竭可以帮助临床医生早日做出决定。


近期,一项发表在杂志Crit Care Med上的研究旨在确定与使用不同的非侵入性氧合技术治疗急性低氧性呼吸衰竭患者插管的相关因素。

此项研究为事后分析的随机临床试验。受试患者为呼吸频率大于25次/分钟且PaO2/FIO2比率小于或等于300mmHg的ICU患者。患者分别接受标准氧气、高流量鼻导管氧气或无创通气。

研究者收集了治疗开始后一小时患者的呼吸变量。在标准氧气下,呼吸频率大于或等于30次/分钟的患者更可能需要插管(OR值2.76;95%CI,1.13-6.75;p = 0.03)。

高流量鼻导管氧后一小时,患者心率的增加是与插管相关的唯一因素。

无创通气开始1小时后,PaO2/FIO2比值小于或等于200 mmHg,潮气量大于9mL/kg是插管的独立预测因子(校正OR值4.26;95%CI,1.62-11.16;p = 0.003,调整后OR值为3.14,95%CI,1.22-8.06;p = 0.02)。此外,无创通气期间潮气量高于9mL/kg与90天死亡率独立相关。

此项研究结果表明:在急性低氧呼吸衰竭患者中,呼吸频率是标准氧气下气管插管的预测指标,但不适用于高流量鼻导管氧气或无创通气。低于200mmHg的PaO2/FIO2和大于9mL/kg的高潮气量是在无创通气下插管的两个有力的预测因子。

原始出处:
Frat JP, Ragot S, et al. Predictors of Intubation in Patients With Acute Hypoxemic Respiratory Failure Treated With a Noninvasive Oxygenation Strategy. Crit Care Med. 2017 Nov 2. doi: 10.1097/CCM.0000000000002818. 

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    2017-11-05 明心见性

    学习了.谢谢分享

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