Am J Gastroenterol:乳糜泻患者难辨梭状芽孢杆菌感染风险增加

2017-11-01 zhangfan MedSci原创

研究证实,乳糜泻患者难辨梭状芽孢杆菌感染风险增加,提示乳糜泻患者肠道免疫和/或微生物组成存在改变的可能性

研究发现乳糜泻患者其结核、流感以及肺炎球菌性肺炎风险增加,近日研究人员考察了乳糜泻患者的难辨梭状芽孢杆菌(CDI)感染风险。

研究人员考察了1969-2008年间,瑞典肠道活检病理证实的乳糜泻患者资料,比较乳糜泻患者与一般人群CDI感染差异。

研究包含28339名乳糜泻患者以及141588名健康对照者,所有参与者无CDI感染史。研究发现乳糜泻患者中,CDI的感染率为56/100000而对照组为26/100000,风险比为2.01(95%,CI,1.64-2.47; P<0.0001)。乳糜泻确诊后的前12个月患者CDI感染风险最高(HR, 5.20; 95% CI, 2.81-9.62; P<0.000),1-5年后的风险降低,但仍高于一般人群(HR,1.85;95% CI,1.22-2.81;P=0.004)。对CDI感染者抗生素使用情况进行分析后显示,乳糜泻患者与对照组在CDI确诊前的抗生素使用无显著差异。

研究证实,乳糜泻患者难辨梭状芽孢杆菌感染风险增加,提示乳糜泻患者肠道免疫和/或微生物组成存在改变的可能性。

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    2018-06-13 许安
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    2017-11-06 thlabcde

    好资料学习了!

    0

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    2017-11-01 明月清辉

    谢谢分享.学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1818927, encodeId=c130181892e06, content=<a href='/topic/show?id=cedc986684d' target=_blank style='color:#2F92EE;'>#难辨梭状芽孢杆菌感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98668, encryptionId=cedc986684d, topicName=难辨梭状芽孢杆菌感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5b3f89, createdName=daviiliu, createdTime=Mon Oct 08 17:00:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075830, encodeId=a7c520e5830e6, content=<a href='/topic/show?id=95b586964dd' target=_blank style='color:#2F92EE;'>#芽孢杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86964, encryptionId=95b586964dd, topicName=芽孢杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69cb413, createdName=chengjn, createdTime=Mon Aug 20 13:00:00 CST 2018, time=2018-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071943, encodeId=9c7d20e19431e, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Jun 13 04:00:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064221, encodeId=8d542064221dd, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Jan 22 05:00:00 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711238, encodeId=8d951e1123827, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Mon Jan 08 23:00:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259235, encodeId=5aa92592353c, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Nov 06 20:09:06 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257747, encodeId=898a25e74774, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Nov 01 09:42:51 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257734, encodeId=e80125e734d7, content=不错的.学习了.学习分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Wed Nov 01 09:28:28 CST 2017, time=2017-11-01, status=1, ipAttribution=)]
    2017-11-01 中医痴

    不错的.学习了.学习分享!

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