BMJ:产前生化筛查与孕产妇心血管疾病长期危险研究

2018-07-12 zhangfan MedSci原创

研究认为,孕妇产前生化指标异常人群需警惕后续心血管事件风险

近日研究人员考察了产前生化筛查异常结果与产后心血管疾病风险之间的关系。

12-55岁,无心血管疾病史的产妇参与研究,接受血清总绒毛膜促性腺激素、雌三醇、妊娠相关血浆蛋白A、α-胎甲球蛋白和二聚体抑制素-A生化筛查。研究的主要终点为孕后冠状动脉、脑血管或外周动脉疾病、心力衰竭或心律失常等心血管事件入院治疗。

855536名孕妇参与研究,平均随访11.4年,总计6209名产妇发生心血管事件。研究发现,所有指标异常,特别是二聚体抑制素-A,均增加产妇后续心血管事件风险。二聚体抑制素-A最高人群(95%以上)其心血管事件风险最大(每10000患者年8.3例vs3.8例)。与没有任何异常生化指标的产妇相比,1个指标异常产妇的后续心血管事件风险增加1.2-1.3倍,2个或以上指标异常产妇的心血管事件风险增加1.5-2.0倍。

研究认为,孕妇产前生化指标异常人群需警惕后续心血管事件风险。

原始出处:


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    2019-05-05 gaoxiaoe
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    2018-07-13 qilu_qi
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    2018-07-13 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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    2018-07-12 龙胆草

    学习谢谢分享

    0