Neuroscience:患者发生卒中后,警惕出现学习功能障碍

2015-12-28 MedSci MedSci原创

认为学习能力支持卒中后的恢复和康复治疗。因此,学习障碍可能会减少恢复的潜力。这里,研究者提出假设,卒中幸存者存在反馈驱动内隐学习障碍。卒中幸存者30例和按照年龄配对的健康对照组21例,受试者学习分类任务,同时对亚组进行功能磁共振扫描(17卒中患者,10名对照患者)。卒中人员学习分类线索比对照组慢。奖励一个笑脸后,当重复这个线索时,卒中幸存者不太可能给出相同的反应。与对照组相比,脑卒中患者苍白球,丘

认为学习能力支持卒中后的恢复和康复治疗。因此,学习障碍可能会减少恢复的潜力。这里,研究者提出假设,卒中幸存者存在反馈驱动内隐学习障碍。

卒中幸存者30例和按照年龄配对的健康对照组21例,受试者学习分类任务,同时对亚组进行功能磁共振扫描(17卒中患者,10名对照患者)。卒中人员学习分类线索比对照组慢。奖励一个笑脸后,当重复这个线索时,卒中幸存者不太可能给出相同的反应。与对照组相比,脑卒中患者苍白球,丘脑,额叶和前额叶皮质和小脑脑活性降低。病变分析显示,存在学习障碍的卒中幸存者,出现额叶,丘脑,尾状核,壳核和脑岛病变。病变侧没有影响学习效果或脑活性。

这些结果显示卒中幸存者存在强化学习障碍,这可能与反馈驱动处理过程,奖赏信号通路和工作记忆障碍相关。

原文出处:

Lam JM, Globas C, Hosp JA, et al. Impaired implicit learning and feedback processing after stroke. Neuroscience. 2015 Nov 27.

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    2016-01-20 王二小小

    学到老

    0

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    2015-12-30 lsndxfj
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    2015-12-30 zhouqu_8
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