Stroke：缺血性卒中与砷暴露相关！

2017-12-07 xing.T MedSci原创

由此可见，在一般人群中砷代谢产物与缺血性脑卒中的发生呈正相关。总的来说，这些发现提示甲基化的砷在卒中发病机制中发挥着潜在的作用，对未来脑血管研究具有重要意义。

近日，卒中领域权威杂志Stroke上发表了一篇研究文章，该病例研究旨在评估尿液中砷水平与缺血性卒中之间的关系。

研究人员在REGARDS (卒中的地理和种族差异原因)队列内嵌套进行了一项病例队列研究。当REGARDS队列中所有发生缺血性脑卒中病例（n=671）纳入研究时，按照区域-种族-性别分层进行随机抽样组建对照亚群（n=2486）。研究人员采用电感耦合等离子体质谱法测定了尿液中基础砷水平。研究人员通过一个随机的子集（n=199）对砷的形态，包括尿无机砷及其代谢产物单甲基酸和二甲基胂酸，进行了测量，并采用加权Cox比例风险模型计算了砷及其产物对缺血性卒中的风险比和95%可信区间。

研究人员对受试者平均随访了6.7年。虽然缺血性卒中显示总砷和总砷没有关联，尿液中单甲基胂酸水平对数增加一个单位，在调整潜在的混杂因素后，缺血性卒中的风险约增加2倍（风险比为1.98；95%可信区间为1.12-3.50）。年龄、种族、性别或地理区域对效果的影响并不明显。

由此可见，在一般人群中砷代谢产物与缺血性脑卒中的发生呈正相关。总的来说，这些发现提示甲基化的砷在卒中发病机制中发挥着潜在的作用，对未来脑血管研究具有重要意义。

原始出处：

Cari L. Tsinovoi,et al. Arsenic Exposure in Relation to Ischemic Stroke The Reasons for Geographic and Racial Differences in Stroke Study.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.117.018891

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2018-07-29 guihongzh

#缺血性#

41 0
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2018-03-28 12498da4m32(暂无昵称)

#缺血性卒#

35 0
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2017-12-12 半夏微凉

学习了谢谢分享

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2017-12-09 lishizhe

#砷#

54 0
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2017-12-09 jyzxjiangqin

缺血性卒中.

64 0
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2017-12-07 戒馋，懒，贪

谢谢分享学习了

64 0
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2017-12-07 lovetcm

大米中含量高

62 0
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2017-12-07 海之蓝

学习

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