Cell Host Microbe:使用离散的DF结构可实现对肠道微生物组及其代谢功能的靶向操控

2020-08-01 MedSci原创 MedSci原创

膳食纤维(DFs)影响肠道微生物组的方式通常被认为是有益的。然而,目前还不知道是否可以通过具有离散化学结构的DFs实现对肠道微生物群,特别是其代谢活动的精确和可预测的管控。

膳食纤维(DFs)影响肠道微生物组的方式通常被认为是有益的。然而,目前还不知道是否可以通过具有离散化学结构的DFs实现对肠道微生物群,特别是其代谢活动的精确和可预测的管控。

 

通过在健康人中使用三种IV型抗性淀粉(RS4s)的剂量反应试验,我们发现结晶和磷酸盐交联的淀粉结构对微生物组组成诱导了分歧的和高度特异性的影响,这些影响与丙酸或丁酸盐输出的定向转变有关。RS4诱导的主导效应在处理组内是显著一致的,在35克/天时呈剂量依赖性的平缓状态,并且可以通过具有不同淀粉代谢途径的细菌类群对RS4s的基质特异性结合和利用来解释。

 

总的来说,这些研究结果支持使用离散的DF结构来实现对肠道微生物组及其与健康相关的代谢功能的定向管控的潜力。

 

原始出处:

 

Edward C DeehanChen Yang, et al., Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production. Cell Host Microbe. 2020 Mar 11;27(3):389-404.e6. doi: 10.1016/j.chom.2020.01.006. 

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    2020-09-27 维他命
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    2021-02-03 xjy02
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    2020-08-01 Arvin0001

    膜拜,学习#肠道微生物#

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