J Dent Res:电动力流动增强F-, Ca2+, K+和Na+离子向釉质的传递

2019-02-04 lishiting MedSci原创

作为牙冠的最外层,釉质是哺乳动物矿化程度最高的组织,它由羟磷灰石晶体构成,其间有长而窄的纳米通道隔断。牙科医学面临的一个主要挑战是如何将不同分子高效可控的渗入到这些纳米孔内。这篇研究的目的是为了评估一种稳定的电动力流动法将不同的离子,如:fluoride (F-), potassium (K+), calcium (Ca++), and sodium (Na+),传输到釉质纳米孔的效果。

作为牙冠的最外层,釉质是哺乳动物矿化程度最高的组织,它由羟磷灰石晶体构成,其间有长而窄的纳米通道隔断。牙科医学面临的一个主要挑战是如何将不同分子高效可控的渗入到这些纳米孔内。这篇研究的目的是为了评估一种稳定的电动力流动法将不同的离子,如:fluoride (F-), potassium (K+), calcium (Ca++), and sodium (Na+),传输到釉质纳米孔的效果。

研究通过荧光显微镜、激光扫描共聚焦显微镜、质量广谱法和离子选择电极技术进行观察和验证。结果显示,不同的离子可以渗入釉质层的整个深度(~1 mm),与弥漫性渗入相比渗透性明显增强。并且,传输深度和速率可以通过渗透时间和电压调控。

结论:这是首次稳定可靠的将阴离子和阳离子传输进釉质纳米孔内的报道。这项技术开启了口腔临床医学中防龋、再矿化、牙齿美白和纳米医药技术传递的新纪元,同时也为向骨组织等传递不同生物材料提供了机遇和挑战。

原始出处:

Peng C, de Sousa FB, et al. Enhanced Delivery of F-, Ca2+, K+, and Na+ Ions into Enamel by Electrokinetic Flows. J Dent Res. 2019 Jan 24:22034518818463. doi: 10.1177/0022034518818463.

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    2019-02-06 TZF0810
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    2019-02-04 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

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