Br J Nutr:非酒精性脂肪肝患者长期补充营养保健品的疗效

2020-08-01 MedSci原创 MedSci原创

本研究中,研究人员在非酒精性脂肪性肝病的受试者中探究了一种天然成分的混合物,即DHA、磷脂酰胆碱、水飞蓟素、胆碱、姜黄素和d-α-生育酚。主要终点为血清肝酶水平,其他肝功能参数、代谢综合征

本研究中,研究人员在非酒精性脂肪性肝病的受试者中探究了一种天然成分的混合物,即DHA、磷脂酰胆碱、水飞蓟素、胆碱、姜黄素和d-α-生育酚。主要终点为血清肝酶水平,其他肝功能参数、代谢综合征和炎症为次要终点。由于非酒精性脂肪肝与止血改变有关,可能会导致该病的血管风险增加,因此也对凝血-纤维蛋白溶解平衡进行了全面调查。

 

本研究涉及两个平行组的双盲、随机、多中心对照试验。纳入NAFLD的受试者(18-80岁,男女不限)接受主动或对照治疗3个月。在补充治疗前和补充治疗结束时,共对113名受试者进行了所有检测。治疗后肝酶天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶和γ-谷氨酰转肽酶从23-2%下降到3-7%,只有AST水平达到统计学意义。但对照组和活动组之间无差异。代谢和炎症变量没有变化,只是活性治疗后胆固醇和葡萄糖水平略有增加(小于10%)。凝血-纤维蛋白溶解参数不受两种治疗的影响。

 

总之,在NAFLD受试者中,慢性补充膳食化合物混合物的耐受性良好,显然是安全的。该试验未能证明对相关生理病理标志物的任何疗效,但其方案和结果可能对设计未来的天然化合物研究有用。

 

原始出处:

 

Chiara CerlettiMario Colucci, et al., Randomised trial of chronic supplementation with a nutraceutical mixture in subjects with non-alcoholic fatty liver disease. Br J Nutr. 2020 Jan 28;123(2):190-197.  doi: 10.1017/S0007114519002484.

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    2020-09-02 lovetcm

    #非酒精性脂肪肝#很难治疗。#保健品#更很难取得实际的效果。

    0

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    2020-08-01 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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