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J Orthop Surg Res：研究揭示LncRNA-ANCR调节骨肉瘤发生发展的机制

2017-09-24 MedSci MedSci原创

LncRNA-ANCR骨肉瘤
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骨肉瘤（OS）是发生在骨的最常见的恶性肿瘤之一，研究已经发现EZH2在各种癌症的发展中起关键作用。既往研究发现LncRNA-ANCR（抗分化ncRNA）与EZH2相互作用并调节成骨细胞分化。本研究旨在探究lncRNA-ANCR对骨肉瘤肿瘤发生的影响，并探讨其潜在的分子机制。研究人员使用RT-PCR检测OS组织和细胞系中lncRNA-ANCR、EZH2、p21和p27的mRNA的水平。使用细胞增殖，

骨肉瘤（OS）是发生在骨的最常见的恶性肿瘤之一，研究已经发现EZH2在各种癌症的发展中起关键作用。既往研究发现LncRNA-ANCR（抗分化ncRNA）与EZH2相互作用并调节成骨细胞分化。本研究旨在探究lncRNA-ANCR对骨肉瘤肿瘤发生的影响，并探讨其潜在的分子机制。

研究人员使用RT-PCR检测OS组织和细胞系中lncRNA-ANCR、EZH2、p21和p27的mRNA的水平。使用细胞增殖，transwell侵袭和迁移测定以评估lncRNA-ANCR耗尽对OS细胞生长的影响。使用RNA pull-down分析检测lncRNA-ANCR和EZH2之间的相互作用。通过交叉表法分析了lncRNA-ANCR的表达与EZH2表达的相关性。

结果显示，OS组织和细胞系中LncRNA-ANCR均高度表达。 lncRNA-ANCR的表达减少可抑制OS细胞的增殖、侵袭和迁移。细胞凋亡率也随着lncRNA-ANCR的过表达而增加。具体来说，lncRNA-ANCR的下调降低了EZH2的mRNA水平，并在mRNA和蛋白质水平上增加了p21和p27的表达。LncRNA-ANCR与EZH2相互作用，且其表达丰度在OS患者中呈正相关。

总之，该研究结果表明，LncRNA-ANCR可能通过与EZH2相互作用及通过调节p21和p27的表达来抑制OS细胞的细胞增殖、迁移和侵袭。

原始出处：

Fei Zhang, Hao Peng. LncRNA-ANCR regulates the cell growth of osteosarcoma by interacting with EZH2 and affecting the expression of p21 and p27. J Orthop Surg Res. 2017; 12: 103. Published online 2017 Jul 5. doi: 10.1186/s13018-017-0599-7

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2005647, encodeId=6dd6200564ea2, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Mon Apr 30 12:12:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2030729, encodeId=c7b92030e2968, content=<a href='/topic/show?id=71353e8964f' target=_blank style='color:#2F92EE;'>#发生发展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37896, encryptionId=71353e8964f, topicName=发生发展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Fri Aug 31 03:12:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248623, encodeId=378a24862329, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Thu Sep 28 23:32:11 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301869, encodeId=53471301869a4, content=<a href='/topic/show?id=b469109e41d' target=_blank style='color:#2F92EE;'>#lncRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10974, encryptionId=b469109e41d, topicName=lncRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Tue Sep 26 08:12:00 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247339, encodeId=ec8c24e339e7, content=不错.医学之路又进了一步!, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/24/98a9fdf63320b855aa852b040ae73bb9.jpg, createdBy=16362157480, createdName=刘守领, createdTime=Sun Sep 24 18:24:22 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247333, encodeId=3eba24e33340, content=不错的.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun Sep 24 18:01:21 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247331, encodeId=957a24e33167, content=标记, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Sun Sep 24 17:23:41 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2018-04-30 yanjie6253_56072842

    #CRN#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2005647, encodeId=6dd6200564ea2, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Mon Apr 30 12:12:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2030729, encodeId=c7b92030e2968, content=<a href='/topic/show?id=71353e8964f' target=_blank style='color:#2F92EE;'>#发生发展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37896, encryptionId=71353e8964f, topicName=发生发展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Fri Aug 31 03:12:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248623, encodeId=378a24862329, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Thu Sep 28 23:32:11 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301869, encodeId=53471301869a4, content=<a href='/topic/show?id=b469109e41d' target=_blank style='color:#2F92EE;'>#lncRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10974, encryptionId=b469109e41d, topicName=lncRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Tue Sep 26 08:12:00 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247339, encodeId=ec8c24e339e7, content=不错.医学之路又进了一步!, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/24/98a9fdf63320b855aa852b040ae73bb9.jpg, createdBy=16362157480, createdName=刘守领, createdTime=Sun Sep 24 18:24:22 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247333, encodeId=3eba24e33340, content=不错的.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun Sep 24 18:01:21 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247331, encodeId=957a24e33167, content=标记, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Sun Sep 24 17:23:41 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2018-08-31 wgsun

    #发生发展#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2005647, encodeId=6dd6200564ea2, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Mon Apr 30 12:12:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2030729, encodeId=c7b92030e2968, content=<a href='/topic/show?id=71353e8964f' target=_blank style='color:#2F92EE;'>#发生发展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37896, encryptionId=71353e8964f, topicName=发生发展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Fri Aug 31 03:12:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248623, encodeId=378a24862329, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Thu Sep 28 23:32:11 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301869, encodeId=53471301869a4, content=<a href='/topic/show?id=b469109e41d' target=_blank style='color:#2F92EE;'>#lncRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10974, encryptionId=b469109e41d, topicName=lncRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Tue Sep 26 08:12:00 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247339, encodeId=ec8c24e339e7, content=不错.医学之路又进了一步!, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/24/98a9fdf63320b855aa852b040ae73bb9.jpg, createdBy=16362157480, createdName=刘守领, createdTime=Sun Sep 24 18:24:22 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247333, encodeId=3eba24e33340, content=不错的.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun Sep 24 18:01:21 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247331, encodeId=957a24e33167, content=标记, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Sun Sep 24 17:23:41 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-28 luominglian113

    学习了.谢谢分享

    0

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    2017-09-26 xzw113

    #lncRNA#

    0

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    2017-09-24 刘守领

    不错.医学之路又进了一步!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2005647, encodeId=6dd6200564ea2, content=<a href='/topic/show?id=6ff1525e13' target=_blank style='color:#2F92EE;'>#CRN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5257, encryptionId=6ff1525e13, topicName=CRN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Mon Apr 30 12:12:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2030729, encodeId=c7b92030e2968, content=<a href='/topic/show?id=71353e8964f' target=_blank style='color:#2F92EE;'>#发生发展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37896, encryptionId=71353e8964f, topicName=发生发展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Fri Aug 31 03:12:00 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=248623, encodeId=378a24862329, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Thu Sep 28 23:32:11 CST 2017, time=2017-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301869, encodeId=53471301869a4, content=<a href='/topic/show?id=b469109e41d' target=_blank style='color:#2F92EE;'>#lncRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10974, encryptionId=b469109e41d, topicName=lncRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Tue Sep 26 08:12:00 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247339, encodeId=ec8c24e339e7, content=不错.医学之路又进了一步!, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/24/98a9fdf63320b855aa852b040ae73bb9.jpg, createdBy=16362157480, createdName=刘守领, createdTime=Sun Sep 24 18:24:22 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247333, encodeId=3eba24e33340, content=不错的.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun Sep 24 18:01:21 CST 2017, time=2017-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247331, encodeId=957a24e33167, content=标记, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Sun Sep 24 17:23:41 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-24 中医痴

    不错的.学习了.谢谢分享!

    0

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    2017-09-24 llaq

    标记

    0