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JCEM：Purkinje细胞蛋白4表达与醛固酮生成腺瘤中DNA甲基化的关系

2017-12-27 MedSci MedSci原创

Purkinje细胞蛋白4醛固酮生成腺瘤DNA甲基化
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大家都知道醛固酮的产生受到醛固酮生成腺瘤（APA）中钙信号激活的刺激，有研究表明表观遗传因子像DNA甲基化可能与参与醛固酮调节的基因的表达有关。而2017年12月26日发表在JCEM上的一篇文章则研究了了APA中与钙信号级联相关的基因甲基化，以及与APA相关的基因突变与DNA甲基化水平的关系。

大家都知道醛固酮的产生受到醛固酮生成腺瘤（APA）中钙信号激活的刺激，有研究表明表观遗传因子像DNA甲基化可能与参与醛固酮调节的基因的表达有关。而2017年12月26日发表在JCEM上的一篇文章则研究了了APA中与钙信号级联相关的基因甲基化，以及与APA相关的基因突变与DNA甲基化水平的关系。

研究人员分析了无功能的肾上腺皮质腺瘤（NF，n=12）及APA(n=35)样本，通过使用慢病毒递送将KCNJ5T158A突变引入人肾上腺皮质细胞系（HAC15细胞）。使用肾上腺肿瘤样品和HAC15细胞进行DNA甲基化阵列分析。

研究结果显示Purkinje细胞蛋白4（PCP4）基因是APA中甲基化最低的基因之一。 PCP4两个位点的DNA甲基化水平与肾上腺肿瘤mRNA表达呈显着负相关。生物信息学和多元回归分析显示CEBPA（CCAAT /增强子结合蛋白α）可能与PCP4启动子的甲基化位点结合。 CEBPA通过染色质免疫沉淀实验与PCP4低甲基化区域结合。 APA基因型之间PCP4甲基化水平无显着差异。此外，KCNJ5 T158A不影响HAC15细胞中的PCP4甲基化水平。

上述研究结果表明PCP4启动子是APA中甲基化最低的启动子之一，PCP4转录可能与APA中的去甲基化以及CEBPA有关。已知导致醛固酮过量表达的KCNJ5突变无论在临床或体外研究中均与PCP4甲基化无关。

原始出处：

Kazuhiro Kobuke.et al. Purkinje cell protein 4 expression is associated with DNA methylation status in aldosterone-producing adenoma. J Clin Endocrinol Metab. 2017.

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    2018-01-25 smallant2015

    #JCEM#

    0

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    2018-09-05 achengzhao

    #JCE#

    0

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    2018-01-01 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2017-12-29 cmsvly

    #醛固酮#

    0

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    2017-12-28 飛歌

    学习了很有用不错

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1777726, encodeId=d2281e77726de, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Jan 25 02:36:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063108, encodeId=e32220631089b, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Wed Sep 05 00:36:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274326, encodeId=30432e43268f, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jan 01 01:44:41 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1379227, encodeId=106e13e92275b, content=<a href='/topic/show?id=ac549564240' target=_blank style='color:#2F92EE;'>#醛固酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95642, encryptionId=ac549564240, topicName=醛固酮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Fri Dec 29 13:36:00 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273082, encodeId=f3b62e30825e, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Thu Dec 28 00:04:06 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273058, encodeId=42e92e3058de, content=谢谢分享.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Dec 27 22:51:50 CST 2017, time=2017-12-27, status=1, ipAttribution=)]
    2017-12-27 清风拂面

    谢谢分享.学习受益匪浅

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