Nat Commun:小肠微生物失调是胃肠功能性疾病相关症状的基础

2020-08-01 MedSci原创 MedSci原创

小肠细菌过度生长(SIBO)一直与功能性胃肠道疾病(FGIDs)的相关症状有关,但其机制仍未明确,治疗涉及广谱抗生素。

小肠细菌过度生长(SIBO)一直与功能性胃肠道疾病(FGIDs)的相关症状有关,但其机制仍未明确,治疗涉及广谱抗生素

 

在此我们表明,基于十二指肠吸液培养的SIBO反映了厌氧菌的过度生长,与患者的症状不一致,可能是饮食偏好的结果。在有症状的患者中小肠微生物成分有明显改变,这与吸液培养结果不一致。

 

在一项试验性干预研究中,我们发现从高纤维饮食转为低纤维、高单糖饮食会引发FGID相关症状,并降低小肠微生物多样性,同时增加小肠通透性。

 

综上所述,我们的研究结果表明,在有胃肠道症状的患者中表征小肠微生物组可能允许更有针对性的抗菌或基于饮食的方法来治疗。

 

原始出处:

 

George B SaffouriRobin R Shields-Cutler, et al., Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders. Nat Commun. 2019 May 1;10(1):2012. doi: 10.1038/s41467-019-09964-7.

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    2021-05-08 liuli5079
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encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Feb 24 06:02:56 CST 2021, time=2021-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805563, encodeId=50598055634a, content=👏👏, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210706/5924e86cc73c43efb5bad9dd92ac0d7b/63609a5527c447f48b59b39dd248a66f.jpg, createdBy=cf0a5102349, createdName=站在塔尖, createdTime=Sat Aug 01 10:54:14 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805561, encodeId=a76380556169, content=在有胃肠道症状的患者中表征小肠微生物组可能允许更有针对性的抗菌或基于饮食的方法来治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/02/28/889a1910ded7780f3c049b354f1648b7.jpg, createdBy=2a791737770, createdName=mswert122, createdTime=Sat Aug 01 10:50:03 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805542, encodeId=fd4e8055422c, content=<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81670, encryptionId=b1fd816e094, topicName=肠道微生物)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 01 10:31:57 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805541, encodeId=f44a805541fc, content=<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>饮食对于肠道菌群的控制作用,其实是比较大的,像中医中说的寒凉饮食怎么样,辛辣饮食怎么样,其实就反映在肠道微生物上面。, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81670, encryptionId=b1fd816e094, topicName=肠道微生物)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 01 10:31:19 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805528, encodeId=8374805528e4, content=👍🏻, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200817/2786f976001a4edd9a06b98ec2527751/bef891b389dd48d8a0076e15cba6fc86.jpg, createdBy=72015403602, createdName=ms5000001908858550, createdTime=Sat Aug 01 10:11:04 CST 2020, time=2020-08-01, status=1, ipAttribution=)]
    2021-02-24 liye789132251
  5. 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encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Feb 24 06:02:56 CST 2021, time=2021-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805563, encodeId=50598055634a, content=👏👏, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210706/5924e86cc73c43efb5bad9dd92ac0d7b/63609a5527c447f48b59b39dd248a66f.jpg, createdBy=cf0a5102349, createdName=站在塔尖, createdTime=Sat Aug 01 10:54:14 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805561, encodeId=a76380556169, content=在有胃肠道症状的患者中表征小肠微生物组可能允许更有针对性的抗菌或基于饮食的方法来治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/02/28/889a1910ded7780f3c049b354f1648b7.jpg, createdBy=2a791737770, createdName=mswert122, createdTime=Sat Aug 01 10:50:03 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805542, encodeId=fd4e8055422c, content=<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81670, encryptionId=b1fd816e094, topicName=肠道微生物)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 01 10:31:57 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805541, encodeId=f44a805541fc, content=<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>饮食对于肠道菌群的控制作用,其实是比较大的,像中医中说的寒凉饮食怎么样,辛辣饮食怎么样,其实就反映在肠道微生物上面。, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81670, encryptionId=b1fd816e094, topicName=肠道微生物)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 01 10:31:19 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805528, encodeId=8374805528e4, content=👍🏻, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200817/2786f976001a4edd9a06b98ec2527751/bef891b389dd48d8a0076e15cba6fc86.jpg, createdBy=72015403602, createdName=ms5000001908858550, createdTime=Sat Aug 01 10:11:04 CST 2020, time=2020-08-01, status=1, ipAttribution=)]
    2020-08-01 站在塔尖

    👏👏

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2087728, encodeId=67da208e72866, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sat May 08 14:02:56 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825177, encodeId=f4c818251e730, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Jun 29 01:02:56 CST 2021, time=2021-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915534, encodeId=2ad5191553419, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Sat Oct 17 04:02:56 CST 2020, time=2020-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1884530, encodeId=bf7a1884530e4, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Feb 24 06:02:56 CST 2021, time=2021-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805563, encodeId=50598055634a, content=👏👏, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210706/5924e86cc73c43efb5bad9dd92ac0d7b/63609a5527c447f48b59b39dd248a66f.jpg, createdBy=cf0a5102349, createdName=站在塔尖, createdTime=Sat Aug 01 10:54:14 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805561, encodeId=a76380556169, content=在有胃肠道症状的患者中表征小肠微生物组可能允许更有针对性的抗菌或基于饮食的方法来治疗。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/02/28/889a1910ded7780f3c049b354f1648b7.jpg, createdBy=2a791737770, createdName=mswert122, createdTime=Sat Aug 01 10:50:03 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805542, encodeId=fd4e8055422c, content=<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81670, encryptionId=b1fd816e094, topicName=肠道微生物)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 01 10:31:57 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805541, encodeId=f44a805541fc, content=<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>饮食对于肠道菌群的控制作用,其实是比较大的,像中医中说的寒凉饮食怎么样,辛辣饮食怎么样,其实就反映在肠道微生物上面。, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81670, encryptionId=b1fd816e094, topicName=肠道微生物)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 01 10:31:19 CST 2020, time=2020-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805528, encodeId=8374805528e4, content=👍🏻, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200817/2786f976001a4edd9a06b98ec2527751/bef891b389dd48d8a0076e15cba6fc86.jpg, createdBy=72015403602, createdName=ms5000001908858550, createdTime=Sat Aug 01 10:11:04 CST 2020, time=2020-08-01, status=1, ipAttribution=)]
    2020-08-01 mswert122

    在有胃肠道症状的患者中表征小肠微生物组可能允许更有针对性的抗菌或基于饮食的方法来治疗。

    0

  7. 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  8. 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    2020-08-01 lovetcm

    #肠道微生物#饮食对于肠道菌群的控制作用,其实是比较大的,像中医中说的寒凉饮食怎么样,辛辣饮食怎么样,其实就反映在肠道微生物上面。

    0

  9. 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    2020-08-01 ms5000001908858550

    👍🏻

    0

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