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SCI REP：氯/磷比值联合碱性磷酸酶作为中国人原发性甲状旁腺功能亢进症的预测指标！

2017-07-08 xing.T MedSci原创

Cl/PO4PHPT预测
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总之，结合Cl/PO4与ALP可能是一种低成本、简单可用的中国人PHPT的预测标志，特别是无法测定PTH的中国偏远地区。此外，由于NPHPT患者的血清钙水平，Cl/PO4结合ALP水平测量在预测NPHPT上具有巨大的潜力。

氯/磷比值（Cl/PO4）已被发现在原发性甲状旁腺功能亢进（PHPT）中发挥作用，但Cl/PO4与ALP水平与原发性甲状旁腺功能亢进症之间的相关性还没有很好得到研究。近日，Scientific reports 杂志上发表了一篇研究文章，研究人员的目的是探讨联合Cl/PO4与ALP对PHPT的预测价值。

研究人员进行了一项横断面回顾性分析，将172例确诊的PHPT患者分为两组：血钙正常的原发性甲状旁腺功能亢进症（NPHPT）组和高钙血症PHPT组。

研究人员发现，Cl/PO4水平和ALP水平在NPHPT和高钙血症PHPT组均显著高于正常对照者。Cl/PO4水平和ALP水平是原发性甲状旁腺功能亢进症的独立危险因素。Cl/PO4结合ALP可以增加受试者工作特征曲线（ROC曲线下面积）以及NPHPT和高钙血症PHPT的诊断价值（0.913；95%可信区间为0.744-1和0.932；95%可信区间为0.897-0.966），特异性为92.8%，敏感性为98%。

总之，结合Cl/PO4与ALP可能是一种低成本、简单可用的中国人PHPT的预测标志，特别是无法测定PTH的中国偏远地区。此外，由于NPHPT患者的血清钙水平，Cl/PO4结合ALP水平测量在预测NPHPT上具有巨大的潜力。

原始出处：

Qianqian Wang,et al. The chloride/phosphate ratio combined with alkaline phosphatase as a valuable predictive marker for primary hyperparathyroidism in Chinese individuals.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-05183-6

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    2018-05-13 jiyangfei

    #原发性#

    0

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    2017-07-10 jmtang

    #甲状旁腺功能亢进#

    0

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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219930, encodeId=d9152199306e, content=谢谢分享谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 08 11:24:37 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-10 anminleiryan

    #预测指标#

    0

  4. 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encryptionId=d90469826e2, topicName=甲状旁腺)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=84ba5566863, createdName=huperzia, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513928, encodeId=ca2815139286c, content=<a href='/topic/show?id=32d33e069ee' target=_blank style='color:#2F92EE;'>#原发性甲状旁腺功能亢进#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37069, encryptionId=32d33e069ee, topicName=原发性甲状旁腺功能亢进)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d7e10601864, createdName=12498877m101暂无昵称, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584011, encodeId=a1531584011bc, content=<a href='/topic/show?id=e9d1e371386' target=_blank 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GetPortalCommentsPageByObjectIdResponse(id=220111, encodeId=ce1f22011187, content=学习过了，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Jul 09 00:02:37 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219948, encodeId=33042199485c, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Sat Jul 08 12:59:14 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219930, encodeId=d9152199306e, content=谢谢分享谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 08 11:24:37 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-10 huperzia

    #甲状旁腺#

    0

  5. 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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219930, encodeId=d9152199306e, content=谢谢分享谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 08 11:24:37 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-10 12498877m101暂无昵称

    #原发性甲状旁腺功能亢进#

    0

  6. 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encryptionId=d90469826e2, topicName=甲状旁腺)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=84ba5566863, createdName=huperzia, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513928, encodeId=ca2815139286c, content=<a href='/topic/show?id=32d33e069ee' target=_blank style='color:#2F92EE;'>#原发性甲状旁腺功能亢进#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37069, encryptionId=32d33e069ee, topicName=原发性甲状旁腺功能亢进)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d7e10601864, createdName=12498877m101暂无昵称, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584011, encodeId=a1531584011bc, content=<a href='/topic/show?id=e9d1e371386' target=_blank 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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219930, encodeId=d9152199306e, content=谢谢分享谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 08 11:24:37 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-10 12498e8em77暂无昵称

    #碱性磷酸酶#

    0

  7. 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createdName=jmtang, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407002, encodeId=be6a140e0028b, content=<a href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452449, encodeId=618514524498e, content=<a href='/topic/show?id=d90469826e2' target=_blank style='color:#2F92EE;'>#甲状旁腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69826, encryptionId=d90469826e2, topicName=甲状旁腺)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=84ba5566863, createdName=huperzia, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513928, encodeId=ca2815139286c, content=<a href='/topic/show?id=32d33e069ee' target=_blank style='color:#2F92EE;'>#原发性甲状旁腺功能亢进#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37069, encryptionId=32d33e069ee, topicName=原发性甲状旁腺功能亢进)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d7e10601864, createdName=12498877m101暂无昵称, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584011, encodeId=a1531584011bc, content=<a href='/topic/show?id=e9d1e371386' target=_blank 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GetPortalCommentsPageByObjectIdResponse(id=220111, encodeId=ce1f22011187, content=学习过了，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Jul 09 00:02:37 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219948, encodeId=33042199485c, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Sat Jul 08 12:59:14 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219930, encodeId=d9152199306e, content=谢谢分享谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 08 11:24:37 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-10 andy2093

    #磷酸酶#

    0

  8. 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createdName=jmtang, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407002, encodeId=be6a140e0028b, content=<a href='/topic/show?id=fa7c100231a5' target=_blank style='color:#2F92EE;'>#预测指标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100231, encryptionId=fa7c100231a5, topicName=预测指标)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10c72588657, createdName=anminleiryan, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452449, encodeId=618514524498e, content=<a href='/topic/show?id=d90469826e2' target=_blank style='color:#2F92EE;'>#甲状旁腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69826, encryptionId=d90469826e2, topicName=甲状旁腺)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=84ba5566863, createdName=huperzia, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513928, encodeId=ca2815139286c, content=<a href='/topic/show?id=32d33e069ee' target=_blank style='color:#2F92EE;'>#原发性甲状旁腺功能亢进#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37069, encryptionId=32d33e069ee, topicName=原发性甲状旁腺功能亢进)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d7e10601864, createdName=12498877m101暂无昵称, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584011, encodeId=a1531584011bc, content=<a href='/topic/show?id=e9d1e371386' target=_blank 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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219930, encodeId=d9152199306e, content=谢谢分享谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 08 11:24:37 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-09 明天会更好！

    学习过了，谢谢分享！

    0

  9. 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encryptionId=d90469826e2, topicName=甲状旁腺)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=84ba5566863, createdName=huperzia, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513928, encodeId=ca2815139286c, content=<a href='/topic/show?id=32d33e069ee' target=_blank style='color:#2F92EE;'>#原发性甲状旁腺功能亢进#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37069, encryptionId=32d33e069ee, topicName=原发性甲状旁腺功能亢进)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d7e10601864, createdName=12498877m101暂无昵称, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584011, encodeId=a1531584011bc, content=<a href='/topic/show?id=e9d1e371386' target=_blank 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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219930, encodeId=d9152199306e, content=谢谢分享谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 08 11:24:37 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 139****5926

    好好文章学习了

    0

  10. 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style='color:#2F92EE;'>#碱性磷酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73713, encryptionId=e9d1e371386, topicName=碱性磷酸酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=335616999328, createdName=12498e8em77暂无昵称, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596025, encodeId=e9f4159602513, content=<a href='/topic/show?id=7b24e386455' target=_blank style='color:#2F92EE;'>#磷酸酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73864, encryptionId=7b24e386455, topicName=磷酸酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584e18318123, createdName=andy2093, createdTime=Mon Jul 10 00:31:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220111, encodeId=ce1f22011187, content=学习过了，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Sun Jul 09 00:02:37 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219948, encodeId=33042199485c, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Sat Jul 08 12:59:14 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219930, encodeId=d9152199306e, content=谢谢分享谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 08 11:24:37 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 清风拂面

    谢谢分享谢谢

    0

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