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NEJM：健康成人肾脏捐献者的肾单位肾小球滤过率

2017-06-15 MedSci MedSci原创

肾脏捐献肾单位肾小球滤过率
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肾小球滤过率(GFR)可以评估所有肾单位的功能，而肾单位肾小球滤过率（GFR）则可以对单个肾单位的功能进行评估。

肾小球滤过率(GFR)可以评估所有肾单位的功能，而肾单位肾小球滤过率（GFR）则可以对单个肾单位的功能进行评估。

我们在梅约诊所和克利夫兰诊所确定了1388个活体肾脏捐献者，运用造影剂对其肾脏进行了CT扫描，在捐献评估过程中基于酞酸盐对GFR进行了测定，并在捐献时进行了肾活检。

平均肾单位肾小球滤过率被计算为GFR除以肾单位的数目(通过CT估计两肾的皮质体积再乘以活组织检查测定的肾小球密度)。人口统计学、临床表现和活检结果与单肾位GFR相关。

捐助者中有58%是妇女，而捐献者的平均(±标准差)年龄为44±12岁 。平均GFR是每分钟115±24ml，每个肾的肾单位的平均数量是860，000±370，000，而平均肾单位肾小球滤过率是每分钟80±40 nl 。肾单位肾小球滤过率在年龄(年龄在70岁以下的捐献者)、性别或身高(身高在190cm以下的捐献者)这些方面没有发生显着变化。较高的肾单位肾小球滤过率与肾活检中更大的肾单位有关，较多的肾小球硬化和动脉粥样硬化与年龄有关。较高的肾单位肾小球滤过率与190cm以上的身高，肥胖，以及终末期肾病的家族病史相关。

在健康成人肾脏捐献者中，肾单位肾小球滤过率在年龄、性别和身高(190cm以下)方面都相当稳定。较高的肾单位肾小球滤过率与某些慢性肾病和肾活检发现的危险因素有关。

原始出处：
Aleksandar Denic, M.D.，Ph.D.，et al. Single-Nephron Glomerular Filtration Rate in Healthy Adults. NEJM. 2017 June.
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    2017-08-04 bettycmoon

    #肾小球滤过#

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    2017-09-18 新生儿张玉军

    #捐献#

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    2017-06-17 1249897bm38(暂无昵称)

    #肾小球滤过率#

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