Lancet infect dis:登革热的全球负担(2013全球疾病负担研究)

2016-02-13 MedSci MedSci原创

原始出处:Dr Jeffrey D Stanaway,Prof Donald S Shepard,et al,The global burden of dengue: an analysis from the Global Burden of Disease Study 2013,lancet,10 February 2016http://www.thelancet.com/journals/la

登革热是全球范围内最常见的虫媒病毒感染,但其负担没有很好的量化。我们在2013年全球疾病负担研究中估计了登革热的死亡率、发病率和疾病负担。

我们通过生存登记,死因推断和和监测数据,利用死因整体造型工具建立模型。根据官方报道的病例和调整我们原始数据中因扩张因素导致的遗漏报道进行建模。总之,我们拥有了130个国家1780country-years 的死亡数据,76个国家1636country-years 的登革热病例报道,评估14个国家的膨胀系数。

我们评估了1990-2013年平均数为每年9221例登革热死亡病例,从1992年的较低数量8277(95%的不确定性估计5353 - 10649),到2010年的峰值11302(6790 - 13722)。2013年整体死亡数576900 (330000–701200),过早死亡可归因于登革热。1990-2013年登革热的发病率大大增加,每十年翻一倍,从1990年的报道病例830万(330万-1720万)到2013年的5840万(2360万-1.219亿)。2013年的统计显示由于中重度登革热导致的残疾和慢性疲劳造成了566000(186 000–1 415 000)年的残疾生存。2013年考虑致命和非致命的结局,登革热产生了114万(73万-198万)的伤残调整生命年。


解释:虽然低于其他的估计,我们的研究结果提供了更多的证据表明,真正有症状的登革热发病率可能低于普遍引用的每年5000万到1亿例。我们估计的死亡率比其他报道要低,要慎重考虑整体的支持的登革热的证据,其死亡率实际上可能是更高的。

原始出处:

Dr Jeffrey D Stanaway,Prof Donald S Shepard,et al,The global burden of dengue: an analysis from the Global Burden of Disease Study 2013,Lancet infect dis,10 February 2016

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    2016-03-18 howi
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