Psychoneuroendocrinology:中科院心理所发现促食欲激素系统影响创伤后应激障碍症状

2018-10-29 沈春蕾 中国科学报

促食欲激素是指一类能够调节促进食欲的激素。日前,中国科学院心理研究所科研团队首次发现了促食欲激素系统对创伤后应激障碍症状的影响。相关研究成果已经发表于国际心理神经内分泌学会会刊。


促食欲激素是指一类能够调节促进食欲的激素。日前,中国科学院心理研究所科研团队首次发现了促食欲激素系统对创伤后应激障碍症状的影响。相关研究成果已经发表于国际心理神经内分泌学会会刊。

中国科学院心理健康重点实验室王力研究组和中科院心理所遗传与生物医学信息学研究中心副研究员张昆林合作,通过近年来的一些研究发现,促食欲激素参与了应激过程的调节,并在应激相关心理疾患中发挥潜在作用。

创伤后应激障碍(PTSD)是一种最为常见的应激相关心理疾患。王力说:“先前的理论与实证研究显示,异常的恐惧记忆调节在其发生机制中具有重要的作用。因此,PTSD可以作为一个十分理想的研究促食欲激素对应激调节效应的心理疾患。通过研究促食欲激素相关基因的突变对人类PTSD症状的影响,有助于增进我们对促食欲激素系统的应激调节效应的认识。”

基于此,科研团队在1134名成人地震幸存者中,考察了泌素受体和食欲素受体基因单核苷酸多态性(SNP)对PTSD症状的影响。研究结果支持了促食欲激素系统对人类应激反应的调节作用,并提示研究者进一步关注不同促食欲激素系统之间的交互作用在恐惧记忆调节中的作用。同时,该结果也提示了临床工作者可以开发针对促食欲激素系统的干预手段作为PTSD潜在的干预手段。

原始出处:

Gen Li,et al.The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms.Psychoneuroendocrinology.Volume 100, February 2019, Pages 131-136

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