J Drugs Dermatol:新型视黄醇换肤术能改善各种皮肤类型的老化和痤疮

2020-06-28 MedSci原创 MedSci原创

面部化学换肤受到光老化、痤疮、黄褐斑患者的追捧。一种先进的、医生强度的表层换肤剂,含有3%的视黄醇和其他紧致和丰盈成分,被开发出来,用于去除角质,改善细纹和皱纹的外观,使皮肤丰满紧致,同时促进肤色明亮

面部化学换肤受到光老化、痤疮、黄褐斑患者的追捧。一种先进的、医生强度的表层换肤剂,含有3%的视黄醇和其他紧致和丰盈成分,被开发出来,用于去除角质,改善细纹和皱纹的外观,使皮肤丰满紧致,同时促进肤色明亮、均匀。

 

一项临床研究评估了3%视黄醇换肤与支持性家庭护理方案在一系列换肤候选者、18-65岁女性、光老化、痤疮、色素沉着或黄褐斑以及有色皮肤中的耐受性、安全性和有效性,并进行2-4次换肤。

 

在医生指导下使用行3%视黄醇换肤配方,间隔6周。光老化皮肤、痤疮、色素沉着/黄褐斑或有色皮肤(Fitzpatrick皮肤类型IV-VI)的受试者接受2-4次换肤,同时接受支持性家庭护理方案。皮肤科医生分级、自我评估和数码摄影记录了耐受性和疗效参数。

 

结果,共24名受试者参加了研究,共进行了78次换肤(光老化组,n=14[有痤疮亚组,n=5];黄褐斑组,n=5;彩色皮肤,n=5)。在医生的指导下,3%视黄醇换肤和家庭护理方案在所有皮肤类型和评估条件下都能很好地耐受。许多受试者在换肤后3天就出现明显的脱皮现象,并在第7天解决。在光损伤组中,皮肤科医生对细纹、皱纹、毛孔粗大、松弛、斑驳的色素沉着、缺乏清晰度/光泽度和整体光损伤的临床分级得到显著改善(P<0.05)。所有组别均可观察到效益,并得到自评的支持。数码摄影显示了剥离后立即几天的耐受性,以及对光损伤的好处。

 

综上所述,该研究结果表明,3%的视黄醇表层换肤在所有皮肤类型的受试者中都有良好的耐受性,是一种有效的美容治疗方法,可以紧致皮肤,改善细纹和皱纹,促进肤色明亮、均匀。

 

原始出处:

 

Neil SadickBrenda L. Edison, et al., An Advanced, Physician-Strength Retinol Peel Improves Signs of Aging and Acne Across a Range of Skin Types Including Melasma and Skin of Color. J Drugs Dermatol. 2019 Sep 1;18(9):918-923.

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    2020-12-01 wangbingxhy
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    2020-12-04 tsing_hit
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    2020-06-28 医鸣惊人

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