Brit J Cancer:肥胖状况和代谢综合征与特定部位癌症的关联

2020-08-01 MedSci原创 MedSci原创

即使在代谢健康的受试者中,肥胖也与五种癌症的风险增加相关,而该研究并未发现这些受试者与其它几种与肥胖相关的癌症的风险增加相关。

肥胖和代谢综合症(MetS)一般同时发生,并且都与癌症风险增加相关。然而,尚不清楚肥胖状态伴有及不伴有MetS是否会增加特定部位癌症的风险。

近日,肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章,研究人员使用了来自英国生物银行的390575名受试者(37-73岁)的数据,这些受试者从2006-2016年入组,平均随访7.8年。肥胖的定义是BMI≥30kg/m2,MetS根据成人治疗小组III(ATP-III)的标准来定义。研究人员使用Cox比例风险模型探究BMI和MetS与22种癌症之间的相关性。

代谢健康型肥胖(MHO)和代谢不健康型肥胖(MUO)分别占总分析样本的6.7%和17.9%,以及所包括的肥胖亚人群的27.1%和72.9%。肥胖与22种癌症中的10种癌症较高的风险独立相关。通过代谢状态分层,MUO表型始终与10种肥胖相关的癌症相关。相反,MHO表型仅与以下五种癌症的风险增加相关:子宫内膜癌、食道癌、肾癌、胰腺癌和绝经后乳腺癌

即使在代谢健康的受试者中,肥胖也与五种癌症的风险增加相关,而该研究并未发现这些受试者与其它几种与肥胖相关的癌症的风险增加相关。

原始出处:

Zhi Cao.et al.Association of obesity status and metabolic syndrome with site-specific cancers: a population-based cohort study.British Journal of Cancer.2020.https://www.nature.com/articles/s41416-020-1012-6

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    2022-03-26 胡国宏
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    2020-08-01 ms3000000449926787

    肥胖真不好,太多相关风险了

    0

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