AM J PSYCHIAT:研究首次发现与神经性厌食症有关的基因位点

2017-05-15 tulip1999 来宝网

在美国有数百万人因过度节食而导致进食障碍,而神经性厌食症被认为是所有精神疾病当中死亡率最高的一种。一项最新研究首次确定了与神经性厌食在相关的基因位点,有助于更好地揭开导致这种疾病的各种原因。

在美国有数百万人因过度节食而导致进食障碍,而神经性厌食症被认为是所有精神疾病当中死亡率最高的一种。一项最新研究首次确定了与神经性厌食在相关的基因位点,有助于更好地揭开导致这种疾病的各种原因。

男性和女性都有可能会患上神经性厌食症。然而,女性可能出现这种进食障碍的几率是男性的两倍半,也就是说,几乎有1%的美国女性是神经性厌食在患者。

此外,据报道,变性人群体更容易患上厌食症和其他进食障碍,大约有16%的变性大学生据说都存在进食障碍。

进食障碍是由各种复杂因素引起的严重心理健康问题,包括心理社会因素、遗传因素以及生物学因素等。

厌食症则是一种致命性疾病。在所有精神疾病当中,厌食症的死亡率最高。死亡可能是不接受治疗的结果,但有五分之一的厌食症相关性死亡由于自杀所致。

这项最新研究首次确定了一个厌食症的重要基因位点。来自查珀尔希尔北卡罗来那大学(UNC)医学院的研究人员为了确定这种精神疾病的遗传基础进行了一项全基因组研究。

这项最新研究是由精神遗传学协会进食障碍工作小组——由来自全球各地研究机构的研究人员所组成的一个国际研究小组完成的。该研究小组是由来自瑞典斯德哥尔摩卡罗林斯卡学院的教授及北卡罗来那大学(UNC)进食障碍卓越研究中心创始主任Cynthia Bulik博士领导的。

这项最新研究成果发表在《美国精神病学杂志》上。

这项研究不仅揭示厌食症与精神病有关,更令人惊讶的是,研究还发现厌食症与代谢性疾病之间也存在明显相关性。

Bulik和同事们发现12号染色体上的基因位点:rs4622308。此前曾报道,这个遗传区域与1型糖尿病和自身免疫性疾病有关。

“神经性厌食症与神经质和精神分裂症之间存在着显着的遗传相关性,证明厌食症确实是一种精神性疾病的观点成立。但是,出乎意料之外的是,我们还发现神经性厌食症与包括身体组份和胰岛素葡萄糖代谢异常等各种代谢性疾病特征之间存在强烈的遗传相关性。这一发现促使我们更进一步地研究代谢因素是如何增加神经性厌食症风险的。”Cynthia Bulik如是说。

原始出处:
Laramie Duncan, Zeynep Yilmaz, Helena Gaspar, et al. Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa. American Journal of Psychiatry, May 12, 2017.

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    2017-05-31 收获你的美

    学习了谢谢分享

    0

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    2017-05-24 卡圣

    学习了,谢谢

    0

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    2017-05-16 baihao215

    喔,厉害了。学习了

    0

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    2017-05-16 meiliwuxian

    那么贪吃的基因呢?

    0

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神经性厌食(AN)的青少年是有闭经,并且有骨量增长减少和低骨矿密度(BMD)。间充质干细胞分化调节是一种调节骨形成的重要因素。前脂肪细胞因子1(Pref-1),一种脂肪细胞和成骨细胞分化的抑制剂,在雌激素缺乏状态下升高。为了探讨AN的青春期女孩雌二醇经皮给药对Pref-1的影响,并检测Pref-1变化与腰椎BMD和骨转换标志物变化之间的关系,来自美国哈佛大学医学院的Anne