IGLH:骨髓活检在南非淋巴瘤诊断和分期中的应用如何?

2018-05-30 MedSci MedSci原创

骨髓活检(BMB)是一种淋巴瘤诊断和分期的工具,尽管在国际分期指南中限制该应用,但其在医疗资源受限的环境中仍然是有用的,有利于减少侵入性的核医学技术使用。 从2005年到2010年,对成人淋巴瘤患者的BMBs进行回顾性实验室数据复查,以确定亚型、骨髓参与率(BMI)、人类免疫缺陷病毒(HIV)血清蛋白和CD4计数、trephine长度和其他。在淋巴瘤中报告的1215个BMBs包括759个新诊

骨髓活检(BMB)是一种淋巴瘤诊断和分期的工具,尽管在国际分期指南中限制该应用,但其在医疗资源受限的环境中仍然是有用的,有利于减少侵入性的核医学技术使用。

2005年到2010年,对成人淋巴瘤患者的BMBs进行回顾性实验室数据复查,以确定亚型、骨髓参与率(BMI)、人类免疫缺陷病毒(HIV)血清蛋白和CD4计数、trephine长度和其他。在淋巴瘤中报告的1215BMBs包括759个新诊断的患者,其中有43.6%为非霍奇金淋巴瘤(NHL) 28.9%为高等级B亚型和35.7%为霍奇金淋巴瘤(HL)。在3个组中,HIV的血清反应率分别为38.8%53.0%33.9%。在Burkitt淋巴瘤和HL中,BMIHIV血清阳性之间存在统计学关联。在新的淋巴瘤病例中,超过10% (n = 79)经辅助检查诊断。在NHL中报道了偶然的组织学不一致和转化。集中或单方面BMI比较少见,双侧BMB和活检长度超过26毫米并不能改善BMI检测。

研究表明,在南非的公共部门,艾滋病毒的高流行导致了来自发达国家的不同的淋巴瘤。出现高BMI指数。在这里,在类似的资源限制条件下,国际淋巴瘤分期准则在逻辑上具有挑战性。BMB在淋巴瘤的分期和诊断中仍然有用,建议使用至少26毫米的经处理的环钻长度的单边取样。

原始出处:

M. Roest, P. , et. al. The utility of bone marrow sampling in the diagnosis and staging of lymphoma in South Africa

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    2018-06-01 smlt2008
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    2018-06-01 hongbochen
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    2018-05-30 1e0f8808m18(暂无匿称)

    学习了.谢谢分享!

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