Mater Sci Eng C Mater Biol Appl:纳米多孔氧化石墨烯/钴金属有机骨架的抗菌性能

2019-10-31 不详 网络

由于GO与金属离子和有机键合键的相对对应关系,基于金属-有机骨架(MOF)的氧化石墨烯(GO)最近备受关注。此外,将GO引入Co-MOF中以制备新的纳米多孔杂化物具有改善的Co-MOF的选择性和稳定性。本研究中,研究人员通过溶剂热法使用钴盐和对苯二甲酸合成氧化石墨烯/钴金属有机骨架(GO/Co-MOF),具有杀菌活性,可抵抗革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌的生长。XRD,傅立叶变换红外

由于GO与金属离子和有机键合键的相对对应关系,基于金属-有机骨架(MOF)的氧化石墨烯(GO)最近备受关注。此外,将GO引入Co-MOF中以制备新的纳米多孔杂化物具有改善的Co-MOF的选择性和稳定性。本研究中,研究人员通过溶剂热法使用钴盐和对苯二甲酸合成氧化石墨烯/钴金属有机骨架(GO/Co-MOF),具有杀菌活性,可抵抗革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌的生长。

XRD,傅立叶变换红外光谱和拉曼光谱证实成功合成了金属有机骨架以及Co-MOF掺入了GO纳米片中。扫描电子显微镜显示GO/Co-MOF呈车轮状结构,透射电子显微镜检查确认了此结构,GO纳米片上装饰了Co-MOF。MTT检测显示,72 h之内,GO/Co-MOF与人成纤维细胞具有生物相容性。当细菌浓度为100μg/mL时,GO/Co-MOF对大肠杆菌和金黄色葡萄球菌的生长抑制作用可达到99%以上。GO基Co-MOF的出色抗菌活性与GO板的锋利边缘的协同作用以及从其表面释放的钴离子(Co2 +)的毒性作用有关。使用DPPH抗氧化剂测定与细胞孵育的样品中GO/Co-MOF自由基清除,确认了对细菌发挥毒性的最低自由基。

综上所述,该研究结果表明,这种新颖的基于氧化石墨烯的MOF具有其固有的优越的多孔结构,高活性的金属配位和商业连接物,是极有希望的候选物,可在生物和制药应用中用作高潜力的持续杀菌材料。

原始出处:

Hatamie S, Ahadian MM, et al., Antibacterial properties of nanoporous graphene oxide/cobalt metal organic framework. Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109862. doi: 10.1016/j.msec.2019.109862. Epub 2019 Jun 15.

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    2020-08-02 sunylz
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    2020-09-24 spoonycyy
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