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Circ-Heart Fail：心衰患者血浆和心肌GAL-3水平可反映炎症和纤维化吗？

2017-03-19 xing.T MedSci原创

GAL-3心肌炎症纤维化
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由此可见，心肌Gal-3可作为心脏炎症和纤维化的可能指标，取决于心脏衰竭的发病机制。然而，循环中Gal-3浓度似乎不能反映心内膜Gal-3水平或心肌纤维化。

半乳糖凝集素（GAL）-3是一种β-半乳糖苷凝集素，并且目前其研究热点是作为心力衰竭的生物标志物。GAL-3也发挥促炎作用，至少在心外组织。近日，心血管领域权威杂志Circ-Heart Fail上发表了一篇研究文章。研究人员旨在明确血浆和心肌GAL-3水平与非缺血性扩张型心肌病和炎症性心肌病（ICMP）患者心肌纤维化和炎症之间的相关性。

研究人员获取了新诊断为心肌病和临床怀疑心肌炎患者的心内膜心肌活检标本和血液样本。根据病理组织学检查结果，患者被分为扩张型心肌病组（n=40）或ICMP组（n=75）。将心内膜心肌活检切片进行组织学检查评估心肌纤维化。

在ICMP患者中，心肌Gal-3的表达与心内膜心肌活检中炎症细胞数目显著相关（r=0.56；P＜0.05）。与此相反，心肌Gal-3的表达与ICMP患者心肌纤维化之间呈负相关（r=-0.59；P＜0.05）。在扩张型心肌病患者中，在左心室活检中，心肌Gal-3的表达与心肌纤维化相关（P=0.63；P＜0.01）。值得注意的是，两组血浆Gal-3水平与心肌Gal-3水平或左心室纤维化不存在相关性，而在ICMP患者的心内膜心肌活检标本中，可以观察到血浆Gal-3水平与炎症细胞数呈正相关关系。

由此可见，心肌Gal-3可作为心脏炎症和纤维化的可能指标，取决于心脏衰竭的发病机制。然而，循环中Gal-3浓度似乎不能反映心内膜Gal-3水平或心肌纤维化。

原始出处：

Christian Besler,et al. Plasma and Cardiac Galectin-3 in Patients With Heart Failure Reflects Both Inflammation and Fibrosis Implications for Its Use as a Biomarker. Circulation：heart failure. 2017.https://doi.org/10.1161/CIRCHEARTFAILURE.116.003804.

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    2017-03-21 docwu2019

    #ART#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1356195, encodeId=ba6a13561959c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Mar 21 07:13:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373332, encodeId=719413e33328b, content=<a href='/topic/show?id=2fd051939ab' target=_blank style='color:#2F92EE;'>#心衰患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51939, encryptionId=2fd051939ab, topicName=心衰患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Tue Mar 21 07:13:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562461, encodeId=a82b1562461a2, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Mar 21 07:13:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181317, encodeId=f54218131ead, content=就是看看，领域不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Mon Mar 20 07:45:33 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181264, encodeId=69ea181264e0, content=每天必做的事就是看medsci, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5gJeAA33pg8XSpMyoXQLg4TTWfCC26g4ibkFFUdQVBtofBwAITTWib8S4f1bKDLaYsKVz2KtVfhLQJoia5mISjlibk/0, createdBy=28331949612, createdName=1e10eabem79(暂无匿称), createdTime=Mon Mar 20 00:02:38 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181178, encodeId=48cd1811e81f, content=好好学习，涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Sun Mar 19 17:00:50 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
    2017-03-21 yuanming7

    #心衰患者#

    0

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    2017-03-21 slcumt

    #HEART#

    0

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    2017-03-20 医艺依意

    就是看看，领域不同

    0

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    2017-03-20 1e10eabem79(暂无匿称)

    每天必做的事就是看medsci

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1356195, encodeId=ba6a13561959c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Mar 21 07:13:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373332, encodeId=719413e33328b, content=<a href='/topic/show?id=2fd051939ab' target=_blank style='color:#2F92EE;'>#心衰患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51939, encryptionId=2fd051939ab, topicName=心衰患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Tue Mar 21 07:13:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562461, encodeId=a82b1562461a2, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Mar 21 07:13:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181317, encodeId=f54218131ead, content=就是看看，领域不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Mon Mar 20 07:45:33 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181264, encodeId=69ea181264e0, content=每天必做的事就是看medsci, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5gJeAA33pg8XSpMyoXQLg4TTWfCC26g4ibkFFUdQVBtofBwAITTWib8S4f1bKDLaYsKVz2KtVfhLQJoia5mISjlibk/0, createdBy=28331949612, createdName=1e10eabem79(暂无匿称), createdTime=Mon Mar 20 00:02:38 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181178, encodeId=48cd1811e81f, content=好好学习，涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Sun Mar 19 17:00:50 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
    2017-03-19 shaosai

    好好学习，涨知识

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