Neurology:早期复发性TIA的特征、频率和结局

2020-07-30 MedSci原创 MedSci原创

该研究是第一个评估早期复发性TIA患者长期结局的研究。该研究的观察结果支持及时发现和治疗早期复发性TIA的重要性,以减少不良临床结局的早期和长期风险。

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,该研究旨在评估早期复发性短暂性脑缺血(TIA)的频率、临床和病因学特征、短期和长期结局。

该前瞻性观察性队列研究纳入了所有转诊至急诊科(ED)并由血管神经科医生诊断的TIA患者。在24小时内进行了快速评估和最佳二级预防。该研究的主要终点为卒中和综合结局,包括卒中、急性冠状动脉综合征和3、12个月时血管死亡,部分患者为60个月;次要结局是TIA复发、脑出血、新发房颤和其他原因导致的死亡。研究人员还评估了TIA与随后卒中病因之间的一致性。

从2010年8月至2017年12月,该研究总共招募了1035例患者(822例TIA,213例TIA复发患者,占21%)。内囊预警综合征和大动脉粥样硬化与早期TIA复发之间的关系最为密切。在每次随访中,早期复发性TIA亚组卒中的风险更高,大多数卒中发作发生在TIA后48小时内。早期复发TIA亚组中,伴有病变、构音障碍和白质软化的TIA是3个月和12个月卒中发生的独立预测因子。TIA和随后的卒中病因学表现具有一致性。ABCD3评分>6预测在整个随访过程中卒中复发的风险更高。

由此可见,该研究是第一个评估早期复发性TIA患者长期结局的研究。该研究的观察结果支持及时发现和治疗早期复发性TIA的重要性,以减少不良临床结局的早期和长期风险。

原始出处:

Matteo Foschi,.et al.Prospective observational cohort study of early recurrent TIA: Features, frequency, and outcome.Neurology.2020.https://n.neurology.org/content/early/2020/07/29/WNL.0000000000010317.abstract

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    2021-12-08 ms2000000371747721

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    2020-12-20 yinhl1978
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    2020-09-24 1378958079

    学习

    0

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