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氘代多不饱和脂肪酸（D-PUFA）治疗老年黄斑变性：前景光明

2020-07-27 Allan MedSci原创

老年黄斑变性RT011氘代多不饱和脂肪酸
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制药公司Retrotope今日宣布，它已开始第二种氘代多不饱和脂肪酸（D-PUFA）候选药物RT011的临床前开发，RT011是氘代二十二碳六烯酸（DHA），其目标是治疗老年黄斑变性（AMD）等眼病。

制药公司Retrotope今日宣布，它已开始第二种氘代多不饱和脂肪酸（D-PUFA）候选药物RT011的临床前开发，RT011是氘代二十二碳六烯酸（DHA），其目标是治疗老年黄斑变性（AMD）等眼病。

Retrotope首席执行官Robert Molinari博士称：“我们开发的首个D-PUFA候选药物RT001已在超过50例患者中显示出强大的安全性，我们希望RT011具有类似的安全性。我们将为这种难以治疗的疾病提供一种全新的药物”。

Retrotope视网膜药物研发工作负责人Karsten Schmidt博士补充说：“光感受器所含的脂质比普通细胞多15倍，其中几乎一半的DHA对视觉功能至关重要，但DHA氧化产生的有毒副产物是AMD和其他多种视网膜萎缩的主要驱动力。氘的稳定作用赋予了DHA抗氧化性，而不会改变DHA的基本功能特性。最初的动物数据证实了RT011能够有效地结合到所有视网膜中，我们对此感到非常鼓舞”。

 

原始出处：

https://www.firstwordpharma.com/node/1743589?tsid=4

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    2020-10-12 wwzzly

    #饱和脂肪酸#

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    2021-01-04 12498ca5m92暂无昵称

    #不饱和脂肪酸#

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    2020-07-29 zblhy

    #PUFA#

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19:57:42 CST 2020, time=2020-07-27, status=1, ipAttribution=)]
    2020-07-29 zll0625

    #多不饱和脂肪酸#

    0

  5. 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    2020-07-29 huangdf

    #变性#

    0

  6. 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    2020-07-29 muzishouyi

    #黄斑#

    0

  7. 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    2020-07-29 斯嘉莉

    #饱和脂肪#

    0

  8. 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    2020-07-29 12498ca5m89暂无昵称

    #老年黄斑变性#

    0

  9. 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    2020-07-27 wxl882001

    了解一下

    0

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