Stroke:长期暴露于空气污染与缺血性卒中后生存有关

2019-02-12 xing.T MedSci原创

由此可见,在中国卒中前PM1和PM2.5暴露与缺血性卒中后一年内发生的致命性缺血性卒中增加有关。改善空气质量可能有利于卒中患者恢复。

由于老年人口众多,已发生卒中,中国承受着沉重的卒中负担。以前的研究已经研究了空气污染与卒中死亡率或住院率之间的关系。然而,空气污染对卒中后存活不利影响的全球证据很少。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员在中国使用了第一个全国医院的卒中前瞻性登记队列,其中包含2007年至2008年期间就诊的12291名缺血性卒中患者。所有患者均接受了1年的卒中后随访,记录随访期间的死亡情况。通过卫星遥控、土地利用信息和气象数据的机器学习算法估算了参与者对环境PM1、PM2.5和PM10(空气动力学直径分别≤1、≤2.5和≤10μm的颗粒物质)和NO2(二氧化氮)的卒中前3年暴露情况。研究人员采用Cox比例风险模型评估空气污染与缺血性卒中后存活率之间的关系。

在1年的随访期间,共发现1649例死亡病例。在控制潜在的混杂因素后,观察到暴露于PM1和PM2.5与发生致命性缺血性卒中之间存在显著关联。PM1和PM2.5每增加10μg/m3的相应风险比和95%CI分别为1.05(1.02-1.09)和1.03(1.00-1.06)。PM10或NO2没有显著关联(风险比和95%CI分别为1.01 [1.00-1.03]和1.03 [0.99-1.06])。对于男性、老年人和肥胖个体,观察到更高的风险比(和95%CI)。

由此可见,在中国卒中前PM1和PM2.5暴露与缺血性卒中后一年内发生的致命性缺血性卒中增加有关。改善空气质量可能有利于卒中患者恢复。

原始出处:


Gongbo Chen.et al.Long-Term Exposure to Air Pollution and Survival After Ischemic Stroke The China National Stroke Registry Cohort.Stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.023264

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    2019-02-13 ylzr123

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

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    2019-02-13 topnew

    学习学习谢谢分享

    0

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    2019-02-12 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2019-02-12 王秀

    学习了,涨知识!

    0

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