Obstet Gynecol:脐带异常与死产

2020-02-10 xing.T MedSci原创

由此可见,脐带异常是死产的重要危险因素,即使使用严格的标准,也占19%的病例。

脐带异常通常被认为是死产的原因,但是有关这些死产的细节很少。近日,妇产科权威杂志Obstetrics and Gynecology上发表了一篇研究文章,研究人员旨在使用严格的标准来归纳与脐带异常相关的死产,并检查相关的危险因素。

死产合作研究网络对2006年至2008年的死产和活产进行了病例对照研究。研究人员使用INCODE(胎儿死亡的初始原因)分类系统对死胎进行了完整的胎儿和胎盘评估以及死亡原因分析。脐带异常定义为脐带卡住(定义为脐带、身体、肩部脐带,并伴有病理检查发现脐带闭塞的证据);通过病理检查发现的结节、扭曲或狭窄、血栓或其他阻塞;脐带脱垂;血管前置;胎儿微循环受损,这被定义为一种组织病理学结果,是血管阻塞的客观证据,当怀疑是死胎的原因时,可用于间接确认脐带异常。研究人员比较了与脐带异常相关的死产和与其他原因死产以及活产女性之间的人口统计学指标和临床因素。其次,研究人员分析了低脐带指数的孕妇亚组。

研究人员通过INDCODE对496个死产婴儿进行了完整的死因分析,其中94个死产婴儿(19%,95%CI 16–23%)死因与脐带异常相关。45个死产婴儿(48%)的胎儿微循环受损,27个死产婴儿(29%)有脐带卡住,26个死产婴儿(27%)脐带打结、扭曲或狭窄,5个死产婴儿(5%)脐带脱垂。没有发生血管前置的病例。除少数例外,脐带异常死胎和非脐带异常死胎之间以及脐带异常死胎和活产之间的孕产妇特征相似。

由此可见,脐带异常是死产的重要危险因素,即使使用严格的标准,也占19%的病例。

原始出处:

Hammad, Ibrahim A.et al.Umbilical Cord Abnormalities and Stillbirth.Obstetrics & Gynecology.2020. https://journals.lww.com/greenjournal/Abstract/publishahead/Umbilical_Cord_Abnormalities_and_Stillbirth.97468.aspx

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