专家视点：Meta分析≠没有门槛

2013-10-24 MedSci MedSci原创

很多人对于Meta分析的初步印象是Meta分析就是一个简单的统计学检验，不用做试验也可以发文章，进而觉得Meta分析是没有门槛的。但这种理解比较片面。Meta分析是指用统计学方法对收集的多个研究资料进行分析和概括，以提供量化的平均效果来回答研究的问题。其优点是通过增大样本含量来增加结论的可信度，解决研究结果的不一致性。Meta分析过程实际上也是一个完整研究的过程，它是文献的量化综述，是以同一课题的

很多人对于Meta分析的初步印象是Meta分析就是一个简单的统计学检验，不用做试验也可以发文章，进而觉得Meta分析是没有门槛的。但这种理解比较片面。

Meta分析是指用统计学方法对收集的多个研究资料进行分析和概括，以提供量化的平均效果来回答研究的问题。其优点是通过增大样本含量来增加结论的可信度，解决研究结果的不一致性。

Meta分析过程实际上也是一个完整研究的过程，它是文献的量化综述，是以同一课题的多项独立研究的结果为研究对象，在严格设计的基础上，运用适当的统计学方法对多个研究结果进行系统、客观、定量的综合分析。

实际上，Meta分析的难易程度无法和实验研究进行比较。只是研究对象和传统研究的客体不同，Meta分析的研究对象是已有研究的结果。Meta分析需要遵循严谨而复杂的方法学，而且因其尽可能全面地纳入针对同一个科学问题的不同研究的结果进行综合分析，所以Meta分析的循证医学等级是优先于单个纳入研究的。

目前，Meta分析是循证医学（Evidence-based Medicine）大量文献分析的核心方法，几乎成了循证医学的代名词，许多杂志也已将Meta分析报告列为原著论文（Original article or Original contribution）。

Meta分析方法正在成为医学科研管理的重要方法。澳大利亚国家医疗卫生研究委员会正在采取临床试验前瞻性注册的方法,以促进Cochrane协作网的活动;印度儿科急性呼吸道感染专业协作组为了确定基于外国试验结果的系统评价是否在印度有效进行了专门研究。Meta分析的最大优点是可以对多个同类型研究进行同质性检验和合并分析,因此,这种方法也可应用于多中心研究不同分中心研究结果的评价、汇总分析和质量控制。

Meta分析在医学领域的应用,为医学实践和科研提供了新的理论和方法，但由于Meta分析属于描述性二次分析,存在混杂偏倚、文献报道偏倚以及分析方法本身的一些缺点,在医学实践和科研中应该正确认识和合理应用Meta分析方法。

国内发表高质量Meta分析案例:

盐摄入和血压的关系：Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials. He, Feng J. et. al. BMJ. 2013, 346:F1325

早期复极心电图改变和心律失常死亡风险：Early Repolarization Pattern and Risk for Arrhythmia Death A Meta-Analysis. Wu Suhua et. al. J Am Coll Cardiol. 2013, 61(6):645-650

Vandetanib联合化疗用于非小细胞肺癌治疗：Chemotherapy plus Vandetanib or Chemotherapy Alone in Advanced Non-small Cell Lung Cancer: A Meta-analysis of Four Randomised Controlled Trials. Xiao YongYing et. al. Clin Oncol. 2013, 25(1):E7-15

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2015-11-13 crystal 丁

正是我需要的

126 0
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2015-07-09 hanhaishenlin

急需关于meta分析选题方面的资料

127 0
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2013-12-15 一闲

#MET#

28 0
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2014-02-24 drshuang

介绍下怎么选题，及文献检索方法。

109 0
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2013-12-08 li98150205

可否指导下META分析的菜鸟，入门级攻略！

102 0
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2013-11-30 nice2seeu

正要学习这方面的内容，谢谢了。

179 0
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2013-11-29 zhang2013

很实用

47 0
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2013-11-09 lindier

学习下

55 0
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2014-03-04 guojianrong

#Meta#

29 0
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2013-11-03 linahan

正是我需要的

104 0

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