Cell Host & Microbe:一物降一物,一种细菌可助控制寨卡病毒流行

2016-05-07 MedSci MedSci原创

巴西研究人员4日说,一种被认为有望控制登革热流行的常见细菌,同样也能帮助控制寨卡病毒流行。研究人员在新一期美国《细胞宿主与寄生体》杂志上报告说,他们的研究证明,给蚊子注射沃尔巴克氏菌后,蚊子传播寨卡病毒的能力大幅下降。沃尔巴克氏菌(Wolbachia)是自然界常见的一种共生菌,蚊子感染后会把这种细菌传给后代,因此能成为应对寨卡疫情一种“现实、有效的选择”。研究人员首先利用感染了寨卡病毒的人类血液喂

巴西研究人员4日说,一种被认为有望控制登革热流行的常见细菌,同样也能帮助控制寨卡病毒流行。

研究人员在新一期美国《细胞宿主与寄生体》杂志上报告说,他们的研究证明,给蚊子注射沃尔巴克氏菌后,蚊子传播寨卡病毒的能力大幅下降。沃尔巴克氏菌(Wolbachia)是自然界常见的一种共生菌,蚊子感染后会把这种细菌传给后代,因此能成为应对寨卡疫情一种“现实、有效的选择”。

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研究人员首先利用感染了寨卡病毒的人类血液喂养蚊子,其中一些蚊子携带沃尔巴克氏菌。两周后发现,携带沃尔巴克氏菌的蚊子体内与唾液内有较少的寨卡病毒基因,而且蚊子唾液内的寨卡病毒没有活性。这意味着,携带沃尔巴克氏菌的蚊子很难传播寨卡病毒。

负责研究的巴西奥斯瓦尔多·克鲁斯基金会的卢西亚诺·莫雷拉指出,注射沃尔巴克氏菌并不是百分之百有效,也不能彻底消灭寨卡病毒,但这种方法可与其他策略如疫苗与灭蚊剂共同使用。

目前,莫雷拉正在与巴西政府卫生机构洽谈,争取获得支持开展野外试验验证沃尔巴克氏菌控制寨卡病毒传播的效果。

此前,研究人员已开始试用沃尔巴克氏菌减少登革病毒传播,并认为这种细菌同样能遏制寨卡病毒流行。新研究首次证明了这一想法的可行性。

原始出处:

Heverton Leandro Carneiro Dutra1, Marcele Neves Rocha1, Fernando Braga Stehling Dias1, 2, Simone Brutman Mansur1, Eric Pearce Caragata1, Luciano Andrade Moreira.Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes.Cell Host & Microbe.doi:10.1016/j.chom.2016.04.021

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小知识:沃尔巴克氏菌

沃尔巴克氏菌常见于节肢动物门和部分线虫体内,影响所寄生动物的生殖和发育。除了影响生殖外,当它们转移到一个新的物种时,会使新寄主产生各种严重的神经系统并发症。2009年开始,科学家发现沃尔巴克氏菌阻止登革热病毒在蚊子体内复制增殖,从而阻隔登革热的传播。概述沃尔巴克氏菌又称为沃尔巴克氏体,属于变形菌纲Proteobacteria的α亚门,立克次氏体科乌巴克体族乌巴克体属中的一种,1924年由Hertig和Wolbach在尖音库蚊Culexpipiens的生殖组织里首次被发现。沃尔巴克氏菌是自然界分布最为广泛的一种共生菌,在鞘翅目、双翅目、半翅目、同翅目、膜翅目、鳞翅目、直翅目和啮目等10多个目的150万一500万种昆虫中都有共生

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    2016-08-15 维他命
  3. 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    2016-07-02 xjy02
  4. 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  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 00:25:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84836, encodeId=5f8284836ab, content=这真的不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 00:24:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84837, encodeId=81b48483e3e, content=看看这个图, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 00:24:00 CST 2016, time=2016-05-09, status=1, ipAttribution=)]
    2016-05-10 吴教授

    也只能从

    0

  6. 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  7. 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  8. 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topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Mon Feb 27 05:08:00 CST 2017, time=2017-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85210, encodeId=aa588521027, content=也只能从, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Tue May 10 07:07:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360000, encodeId=a298136000034, content=<a href='/topic/show?id=6783466083f' target=_blank style='color:#2F92EE;'>#寨卡病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 00:25:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84836, encodeId=5f8284836ab, content=这真的不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 00:24:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84837, encodeId=81b48483e3e, content=看看这个图, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 00:24:00 CST 2016, time=2016-05-09, status=1, ipAttribution=)]
    2016-05-09 stead

    那预期的效果肯定不错

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 00:25:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84836, encodeId=5f8284836ab, content=这真的不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 00:24:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84837, encodeId=81b48483e3e, content=看看这个图, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 00:24:00 CST 2016, time=2016-05-09, status=1, ipAttribution=)]
    2016-05-09 stead

    这真的不错

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 00:25:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84836, encodeId=5f8284836ab, content=这真的不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 00:24:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84837, encodeId=81b48483e3e, content=看看这个图, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Mon May 09 00:24:00 CST 2016, time=2016-05-09, status=1, ipAttribution=)]
    2016-05-09 stead

    看看这个图

    0

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