隐匿性异位嗜铬细胞瘤的麻醉处理1例

2017-12-24 佚名 吉林医学

患者,男,18岁,体重60kg

【一般资料】

患者,男,18岁,体重60kg

【主诉】

因防锈漆中毒就诊于当地医院B超示:腹膜后胰头后缘实性占位。为进一步治疗来我院就诊。

【体格检查】

T36.5℃,HR63次/min,Bp110/68mmHg(1mmHg=0.1333kPa)。术前血、尿常规,肝、肾功能,血糖,电解质,ECG,胸片等检查均正常。

【辅助检查】

CT所见:腹膜后腹主动脉,下腔静脉与胰头后缘之间类圆形软组织块影,大小2.5cm×4.0cm×4.4cm,考虑占位性病变,淋巴瘤可能性大。

【初步诊断

腹膜后包块

【治疗】

拟于全身麻醉下行剖腹探查备肿物切除术。患者入手术室后Bp148/77mmHg,HR73次/min,SpO295%。行右颈内静脉穿刺置管,肌内注射阿托品0.3mg,咪达挫仑2mg。10min后Bp126/70mmHg,HR78次/min。麻醉诱导:静脉滴注咪达唑仑3mg,芬太尼0.3mg,依托咪酯20mg,维库溴铵8mg,插管顺利。IPPV设定:Vt500ml,RR12次/min,I:E=1:1.5,术中持续泵入丙泊酚,瑞芬太尼。手术开始时Bp122/68mmHg,HR86次/min,SpO2100%。打开腹腔探查肿瘤位于胰头后方,下腔静脉与门静脉之间,压迫下腔静脉,向后紧贴腹主动脉。在探查肿瘤过程中Bp反复骤然升高>180/110mmHg,HR>120次/min,加深麻醉效果不明显。静脉滴注酚妥拉明5mg后血压下降至135/75mmHg,当再次探查肿瘤时血压又骤升达190/120mmHg,HR140次/min,将这一情况通报给手术医生,共同商讨病情,高度怀疑嗜铬细胞瘤可能。立即暂停手术,急行左桡动脉穿刺直接动脉测压,加快输液速度,晶胶结合进行扩容。迅速静脉滴注甲泼尼龙琥珀酸钠40mg,硝普钠1~3ug/(kg`min)持续菜注,术中当收缩压>180mmHg或舒张压>100mmHg时间断静脉给予酚妥拉明控制血压并间断静推艾司洛尔控制心率,Bp控制在140/95mmHg,HR90次/min左右,待夹断瘤蒂部血管前加快补液速度,切除肿瘤后Bp骤降至60/30mmHg,停用硝普钠立即静脉滴注去氧肾上腺素100ug并以去甲肾上腺素0.5pg/(kg·min)持续泵注,维持血压在105/60mmHg,HR90次/min左右。手术顺利,历时260min,出血约250ml,尿量750ml,术中共输入液体5000ml。术毕送麻醉恢复室观察,待患者自主呼吸恢复良好,生命体征稳定,清醒拔管,接静脉镇痛菜后安返病房。术后病理切片免疫组化结果示:Ki-67(+,1%&S),mel〇n-A(-),S-100(-),EMA(-),a-inhibin(+),NSE(+),CgA(+),Syn(+),Vim(+),CK(-),支持嗜铬细胞瘤。

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    2017-12-31 祝您健康

    学习

    0

  4. 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    2017-12-30 祝您健康

    学习很重要

    0

  5. 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    2017-12-30 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  6. 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    2017-12-29 祝您健康

    学习

    0

  7. 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    2017-12-28 祝您健康

    医生人才济济生命相托在所不辞.走过春夏秋冬医患矛盾没得关系.白衣战士受气受累愿您富贵平安!

    0

  8. 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createdName=大爰, createdTime=Wed Dec 27 09:28:57 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272758, encodeId=fe662e2758a8, content=学习很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/22/005b55a98a8b2e8ec8bd5577813de704.jpg, createdBy=29fc2176768, createdName=祝您健康, createdTime=Tue Dec 26 21:42:37 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475876, encodeId=b34814e5876a2, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Tue Dec 26 08:15:00 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
    2017-12-27 大爰

    学习了谢谢分享!!

    0

  9. 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    2017-12-26 祝您健康

    学习很重要

    0

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嗜铬细胞瘤和副神经节瘤是起源于位于肾上腺髓质(嗜铬细胞瘤)及其它肾上腺素能系统(副神经节瘤)的嗜铬组织的肿瘤;临床上分泌大量儿茶酚胺激素引起高血压及其它剧烈的心血管症状;既往的研究发现它们往往还能损害糖耐量。然而,这些肿瘤对胰岛素敏感性和胰岛素分泌的影响还不清楚。因此,来自日本的科学人员探讨了嗜铬细胞瘤或副神经节瘤对糖耐量的影响,并综合分析了这些肿瘤患者的胰岛素分泌和胰岛素敏感性相关的各种参数。研

血压高达210/120 mmHg,究竟是谁在捣鬼?

昨天收治了一例高血压危象的患者,庆幸的是,由于患者就医及时,处理得当,病情很快得到了控制,现在病人正处在恢复期,进修的医生让我讲一下高血压危象的知识。

罕见的心脏嗜铬细胞瘤3例

肾上腺外的嗜铬细胞瘤也称为副神经节瘤,多发于腹部。原发于心脏的嗜铬细胞瘤源于副神经节和内脏自主神经副神经节,最多见于左心房。由于肿瘤常累及瓣膜或冠状动脉血供,手术切除困难,预后一般较差。心脏嗜铬细胞瘤较少见,其临床表现有哪些?如何定位诊断和治疗?详见以下3则精选病例——