JAMA SURGERY:18FFDG-PET诊断高风险肺结节

2017-11-23 MedSci MedSci原创

临床上常用F18标记的FDG-PET评估可疑为肿瘤的肺结节。JAMA SURGERY近期发表了一篇文章,研究FDG-PET在不同肿瘤发病率人群中恶性肿瘤诊断的表现。

临床上常用F18标记的FDG-PET评估可疑为肿瘤的肺结节。JAMA SURGERY近期发表了一篇文章,研究FDG-PET在不同肿瘤发病率人群中恶性肿瘤诊断的表现。该研究为一项多中心回顾性研究,纳入2005到2015年间已知或怀疑肺癌的患者共1188例。最终是肿瘤还是良性疾病通过病理诊断,或影像学随访稳定至少18个月。最终纳入的患者绝大部分为超过60岁的男性吸烟患者。总癌症发病率为81%。平均结节尺寸为22mm。PET/CT敏感度和特异度分别为90.1%和39.8%。1188例患者中有136例出现假阳性。阳性预测值和阴性预测值分别为86.4%和48.7%。在logistics回归模型中,结节尺寸大和人群肿瘤发病率高与PET准确性显着相关。随着梅奥模型预测的肿瘤可能性增高,PET/CT阳性预测值增高,而特异性和阴性预测值降低。文章最后认为,在不同肿瘤发病率人群中均观察到高的假阳性率。对于高度怀疑肺癌的患者常规PET/CT扫描不能作为无病诊断的可靠诊断指标。针对高患病率人群应优先使用侵入性组织检查方式,如CT引导下细针穿刺,导航支气管镜以及支气管超声等。原始出处:Amelia W.Maig

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    2018-04-08 chg121
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    2018-02-21 feather89
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    2017-11-25 sunfeifeiyang

    0

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    2017-11-24 jihuaijun1112

    学习学习学习

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  8. [GetPortalCommentsPageByObjectIdResponse(id=2021600, encodeId=1b572021600de, content=<a href='/topic/show?id=31e8e9669d' target=_blank style='color:#2F92EE;'>#GER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7966, encryptionId=31e8e9669d, topicName=GER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Thu May 10 20:20:00 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862043, encodeId=4e771862043b1, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Tue Dec 26 00:20:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877712, encodeId=db1218e77122e, content=<a href='/topic/show?id=b013169237f' target=_blank style='color:#2F92EE;'>#surgery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16923, encryptionId=b013169237f, topicName=surgery)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Sun Apr 08 06:20:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726888, encodeId=d3071e268889a, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Feb 21 08:20:00 CST 2018, time=2018-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264063, encodeId=e72b26406391, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Nov 25 01:31:37 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331078, encodeId=12f313310e812, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI5PdY90y5Jib8FnPhCXTR2d9v3K17epNSwB2eb0vmXUldNJl2e72S4unZTAHLAojicdVSialTDFHAxA/132, createdBy=78d82500042, createdName=ms7514935887898259, createdTime=Sat Nov 25 01:20:00 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263769, encodeId=7d4d263e69a2, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Fri Nov 24 00:15:30 CST 2017, time=2017-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263647, encodeId=662726364e73, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu Nov 23 15:27:06 CST 2017, time=2017-11-23, status=1, ipAttribution=)]
    2017-11-23 三生有幸9135

    学习一下谢谢分享

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