印度国家研究协会关于急性肝衰竭的共识声明(第2部分):急性肝衰竭的管理

2020-10-05 J Clin Exp Hepatol . Sep-Oct 2020;10(5):477-517

急性肝衰竭(ALF)并非常见疾病(如急性肝炎)的常见并发症。病毒性肝炎继之以抗结核药引起的肝毒性是印度ALF的最常见原因。临床上,此类患者表现为黄疸,脑病和凝血病。肝性脑病(HE)和脑水肿是ALF过程

中文标题:

印度国家研究协会关于急性肝衰竭的共识声明(第2部分):急性肝衰竭的管理

英文标题:

Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure

发布机构:

发布日期:

2020-10-05

简要介绍:

急性肝衰竭(ALF)并非常见疾病(如急性肝炎)的常见并发症。病毒性肝炎继之以抗结核药引起的肝毒性是印度ALF的最常见原因。临床上,此类患者表现为黄疸,脑病和凝血病。肝性脑病(HE)和脑水肿是ALF过程中最重要的临床事件,其次是叠加感染,并决定了这些患者的预后。 ALF中脑病和脑水肿的发病机制是独特且多因素的。氨在发病机理中起着至关重要的作用,几种疗法旨在纠正这种异常。新型降氨剂的作用仍在发展中。这些患者最好在具有肝移植设施(LT)的三级医院进行治疗。积极的强化医疗管理已被证明可以挽救大部分患者。在那些预后较差的患者中,LT是已显示可提高生存率的唯一有效疗法。然而,如何识别合适的预后不良的患者仍然是一个挑战。密切监测,及早发现并治疗并发症,以及为移植提供帮助是管理此类患者的一线方法。最近的研究表明,使用动态预后模型更好地选择进行肝移植的患者,及时移植可以挽救预后不良的ALF患者的生命。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=998921, encodeId=fd979989216a, content=很实用, beContent=null, objectType=guider, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=988d5417384, createdName=一缕阳光 Lee, createdTime=Mon Jul 12 22:23:49 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957660, encodeId=15f895e66084, content=厉害,学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=57675481111, createdName=ms5000001865440840, createdTime=Fri Apr 16 18:13:54 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893637, encodeId=6dce89363ecb, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef902474539, createdName=风2019, createdTime=Wed Oct 21 23:59:31 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=893187, encodeId=361c89318ead, content=👍️👍️👍️, beContent=null, objectType=guider, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75bf5427460, createdName=ms7000001443645130, createdTime=Mon Oct 19 23:30:28 CST 2020, time=2020-10-19, status=1, ipAttribution=)]
    2021-07-12 一缕阳光 Lee

    很实用

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    2021-04-16 ms5000001865440840

    厉害,学习了

    0

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    2020-10-21 风2019

    学习了

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    2020-10-19 ms7000001443645130

    👍️👍️👍️

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