05/08/2024
Research Article
Mutations in the microtubule regulatory protein Katnal2 have been linked to autism. Ryeonghwa Kang, Kyungdeok Kim, Yewon Jung, Eunjoon Kim and co-workers find that loss of Katnal2 in mice leads to autism-related phenotypes, which are driven in part by altered ciliary function in the lateral ventricles.
Image credit: pbio.3002596
Current Issue April 2024
05/07/2024
Research Article
Toxoplasma gondii relies on specialized secretory organelles for invasion and host cell manipulation. Justin Quan, Peter Bradley and co-authors characterize all Tre2-Bub2-Cdc16 (TBC) domain-containing proteins in T. gondii, identifying TBC9 as an essential regulator of the GTPase Rab2 that controls intracellular vesicular trafficking.
Image credit: pbio.3002634
05/07/2024
Research Article
Parth Raval, Alexander MacLeod and Sven Gould trace the evolutionary history of plant plastid and mitochondrial proteomes, revealing that major changes in organelle biology may have facilitated plant diversification and the emergence of major plant lineages such as the land plants.
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Image credit: pbio.3002608
05/07/2024
Methods and Resources
Teneurins and latrophilins are cell adhesion molecules that form a transsynaptic complex implicated in hippocampal circuit assembly. Kif Liakath-Ali, Rebecca Refaee and Thomas Südhof provide a spatiotemporal map of teneurin and latrophilin expression in the hippocampus of mice during early development.
Image credit: pbio.3002599
05/07/2024
Methods and Resources
Commonly used genome browsers only show one genome assembly at a time and cannot show comparisons between multiple genomes. Sanjida Rangwala, Valerie Schneider and colleagues develop the Comparative Genome Viewer (CGV), a new visualization tool that aids in the pairwise comparison of whole-genome eukaryotic assembly-assembly alignments.
Image credit: pbio.3002405
05/07/2024
Research Article
Michalina Kazek, Lenka Chodáková, Tomáš Doležal and co-workers characterize the metabolic changes underlying immune cell activation in infected Drosophila larvae, showing that increases in glucose and trehalose uptake, and flux through the cyclic pentose phosphate pathway, are important for both effective immune responses and host protection.
Image credit: Lenka Chodáková
04/16/2024
Unsolved Mystery
This Unsolved Mystery article explores how genome reduction alters endosymbiont biology and highlights a ‘tipping point’ where the loss of the ability to build a cell envelope coincides with a marked erosion of translation-related genes.
Image credit: pbio.3002577
04/12/2024
Editorial
Thomas Richards and Nancy Moran discuss our new collection of articles exploring emerging themes in symbiosis research, as researchers exploit modern research tools and new models to unravel how symbiotic interactions function and evolve.
Image credit: Estelle Kilias
04/12/2024
Perspective
Rhizopus microsporus is a fungal holobiont, harboring bacterial and viral endosymbionts. Laila Partida-Martínez explores how these microbial allies increase pathogenicity and defense and control reproduction in the fungus.
Image credit: pbio.3002587
04/12/2024
Essay
Endosymbiosis is common and has played an important role in the evolution of complex life. Michael Brockhurst, Duncan Cameron and Andrew Beckerman explore the theory and experimental evidence for trade-offs in the early-stage evolution of endosymbiosis.
Image credit: pbio.3002580
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
The green collection explores biological solutions that could be applied to reduce CO2 emissions, get rid of non-degradable plastics, produce food in a sustainable manner or generate energy.
This collection explores potential solutions to mitigate the impacts of human activity on ocean ecosystems to minimize or reverse degradation.
May 19 - 24
Meet Editor in Chief Nonia Pariente (npariente@plos.org)
May 29 - Jun 2
Meet Senior Editor Luke Smith (lsmith@plos.org)
June 9 - 14
Meet Senior Editor Ines Alvarez-Garcia (ialvarez-garcia@plos.org)
June 13 - 17
Meet Editor in Chief Nonia Pariente (npariente@plos.org)
June 18 - 21
Meet Associate Editor Melissa Vazquez Hernandez (mvazquezhernandez@plos.org)
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