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CTLA4+CD4+CXCR5-FOXP3+ T cells associate with unfavorable outcome in patients with chronic HBV infection

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

Background A major barrier to achieving a favorable outcome of chronic HBV infection is a dysregulated HBV-specific immune response resulting from imm......

Platelet-derived extracellular vesicles promote endothelial dysfunction in sepsis by enhancing neutrophil extracellular traps

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

BackgroundThe role of platelet-derived extracellular vesicles (PEVs) in the development of sepsis was investigated in this study.MethodsAfter collecti......

Sec1 regulates intestinal mucosal immunity in a mouse model of inflammatory bowel disease

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

Inflammatory bowel disease (IBD) is a common immune-mediated condition with its molecular pathogenesis remaining to be fully elucidated. This study ai......

Patients with indolent lymphomas are at high risk of infections: experience from a German outpatient clinic

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

BackgroundP:atients with indolent B-cell non-Hodgkin lymphomas (B-NHLs) have an increased risk of infections which is caused by pathomechanisms of the......

Higher cytotoxic activities of CD8+ T cells and natural killer cells from peripheral blood of early diagnosed lung cancer patients

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

IntroductionCytotoxic (CD8+) and natural killer (NK) cells play critical roles in anti-tumor immunity. Dysfunction in these cells is considered as one......

Transcriptomic analysis identifies CYP27A1 as a diagnostic marker for the prognosis and immunity in lung adenocarcinoma

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

BackgroundThe association between lipid metabolism disorder and carcinogenesis is well-established, but there is limited research on the connection be......

The upregulation of peripheral CD3-CD56+CD16+ natural killer cells correlates with Th1/Th2 imbalance in asthma patients during acute upper respiratory viral infections

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

Purpose The aim of this study is to clarify the changes of peripheralCD3(-)CD56(+)CD16(+) NK cells and their correlation with Th1/Th2 immunity profile......

Fasciola gigantica vaccine construct: an in silico approach towards identification and design of a multi-epitope subunit vaccine using calcium binding EF-hand proteins

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

Continuous attempts have been made to pinpoint candidate vaccine molecules and evaluate their effectiveness in order to commercialise such vaccines fo......

A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

BackgroundThe anglerfish, belonging to the teleost order Lophiiformes, are a diverse and species-rich group of fish that are known to exhibit a number......

Efficacy and safety of immune checkpoint inhibitors in Proficient Mismatch Repair (pMMR)/Non-Microsatellite Instability-High (non-MSI-H) metastatic colorectal cancer: a study based on 39 cohorts incorporating 1723 patients

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

PurposeThis study was designed to investigate the efficacy and safety of immune checkpoint inhibitors (ICIs)-based therapy in proficient mismatch repa......

Bcl-3 regulates T cell function through energy metabolism

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

BackgroundBcl-3 is a member of the I kappa B protein family and an essential modulator of NF-kappa B activity. It is well established that Bcl-3 is cr......

Development and validation of a machine learning-based nomogram for predicting HLA-B27 expression

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

BackgroundHLA-B27 positivity is normal in patients undergoing rheumatic diseases. The diagnosis of many diseases requires an HLA-B27 examination.Metho......

Humoral immune response and changes in peritoneal cell populations in rats immunized against two Leptospira serovars; serovar patoc and serovar pyrogenes

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

Background Leptospirosis is a zoonotic disease caused by Leptospira species. Variations in lipopolysaccharide (LPS) structure in Leptospira are known ......

Long-term humoral and cellular immunity after primary SARS-CoV-2 infection: a 20-month longitudinal study

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

BackgroundSARS-CoV-2 remains a world-wide health issue. SARS-CoV-2-specific immunity is induced upon both infection and vaccination. However, defining......

Prevention of M2 polarization and temporal limitation of differentiation in monocytes by extracellular ATP

期刊: BMC IMMUNOLOGY, 2023; 24 (1)

BackgroundElevated levels of extracellular adenosine triphosphate (ATP) modulate immunologic pathways and are considered to be a danger signal in infl......

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