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Snakebite envenomings in the Republic of Korea from the 1970s to the 2020s: A review

期刊: TOXICON, 2021; 196 ()

Snakebite envenomings remain a neglected disease across the globe causing severe injuries and death. An understanding of regional snakebite patterns i......

Epsilon toxin from Clostridium perfringens induces toxic effects on skin tissues and HaCaT and human epidermal keratinocytes

期刊: TOXICON, 2021; 198 ()

Epsilon toxin (ETX) is a key pathogenic factor of C. perfringens type B and D, causing fatal enterotoxemia in sheep and goats. Excessive production of......

The effect of ochratoxin A on cytotoxicity and glucose metabolism in human esophageal epithelium Het-1A cells

期刊: TOXICON, 2021; 198 ()

Ochratoxin A (OTA) is a widespread mycotoxin worldwide that causes major health risks. The esophageal epithelium is unavoidably exposed to food contam......

Research progress on the protection and detoxification of phytochemicals against aflatoxin B-1-Induced liver toxicity

期刊: TOXICON, 2021; 195 ()

Aflatoxin B-1 (AFB(1)) is a potent hepatotoxic toxin, which can cause hepatitis, cirrhosis, and liver immunological damage. It has been involved in th......

Glycyrol alleviates the combined toxicity of fumonisin B1 and cadmium in vitro and in vivo

期刊: TOXICON, 2021; 200 ()

Fumonisin B1 (FB1) is a major food-borne mycotoxin commonly found in maize and maize-based products, while cadmium is one of the most common toxic hea......

Extracorporeal membrane oxygenation combined with sequential blood purification in the treatment of myocardial damage and cardiac arrest caused by mushroom poisoning

期刊: TOXICON, 2021; 197 ()

Mushroom poisoning is a common clinical problem. Severe mushroom poisoning often causes liver and kidney failure. Although severe myocardial damage is......

Insects-plants-pathogens: Toxicity, dependence and defense dynamics

期刊: TOXICON, 2021; 197 ()

In a natural ecosystem, the pathogen-plant-insect relationship has diverse implications for each other. The pathogens as well as insect-pests consume ......

The decreased expression of integrin alpha v is involved in T-2 toxin-induced extracellular matrix degradation in chondrocytes

期刊: TOXICON, 2021; 199 ()

T-2 toxin is one of the most toxic and common mycotoxins in grains and related products. It is considered a risk factor for Kashin-Beck disease (KBD),......

Do pit vipers assess their venom? Defensive tactics of Deinagkistrodon acutus shift with changed venom reserve

期刊: TOXICON, 2021; 199 ()

To maximize survival probability, animals must assess predation risks and adopt flexible defensive strategies based on specific conditions. Pit vipers......

The rapid development of the first instar telson with venom secretion highlights the remarkable survival ability of scorpions

期刊: TOXICON, 2021; 200 ()

The scorpion venom system plays a critical role in capturing prey and defending against predators. In this study, the rapid developmental process of t......

Effect of carboxymethyl chitosan on the detoxification and biotransformation of paralytic shellfish toxins in oyster Ostrea rivularis

期刊: TOXICON, 2021; 196 ()

Economic bivalve ingested toxic algae causes frequent human poisoning events. To explore new compounds that can accelerate the depuration of toxins in......

Melittin inhibits lung metastasis of human osteosarcoma: Evidence of wnt/beta-catenin signaling pathway participation

期刊: TOXICON, 2021; 198 ()

Melittin is a major active peptide component of bee venom that has been demonstrated to show anti-tumor effects. Osteosarcoma is a type of bone tumor ......

Two new cationic alpha-helical peptides identified from the venom gland of Liocheles australasiae possess antimicrobial activity against methicillin-resistant staphylococci

期刊: TOXICON, 2021; 196 ()

Methicillin-resistant staphylococci have become growing threats to human health, and novel antimicrobials are urgently needed. Natural antimicrobial p......

Induction of anti-Zearalenone immune response with mimotopes identified from a phage display peptide library

期刊: TOXICON, 2021; 199 ()

Zearalenone (ZEN), a type of non-steroidal estrogenic mycotoxin, is mainly produced by several species of Fusarium molds. It is ubiquitous in contamin......

MicroRNA-mRNA expression profiles and functional network after injection of botulinum toxin type A into submandibular glands

期刊: TOXICON, 2021; 199 ()

Botulinum toxin type A (BTXA) is effective for the treatment of sialorrhea. MicroRNAs (miRNAs) have significant functions in salivary diseases, but th......

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