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Metformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Background: Non-alcoholic fatty liver disease (NAFLD) is one of the primary causes of chronic liver disease and is closely linked to insulin resistanc......

In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Objective: This study aims to investigate the preparation of sustained-release microcapsules of salvianolic acid. Methods: The stability of salvianoli......

Comparison of Outcomes in Patients with Obesity Between Two Administration Routes of Omeprazole After Laparoscopic Sleeve Gastrectomy: An Open-Label Randomized Clinical Trial

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Background: The effect of different administration routes of omeprazole remains unclear on the recovery in patients with obesity after laparoscopic sl......

Mechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Background: Endometrial cancer (EC) is one of the most common gynaecological malignancies, and its incidence has been rising over the past decade. Tet......

The Agonists of Peroxisome Proliferator-Activated Receptor-gamma for Liver Fibrosis

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Liver fibrosis is a common link in the transformation of acute and chronic liver diseases to cirrhosis. It is of great clinical significance to study ......

Progress in Redirecting Antiparasitic Drugs for Cancer Treatment

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Drug repurposing is a feasible strategy in developing novel medications. Regarding the cancer field, scientists are continuously making efforts to red......

An Update Review of Biosimilars of Adalimumab in Psoriasis-Bioequivalence and Interchangeability

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Biologic drugs have revolutionized the treatment of psoriasis and other rheumatological diseases. In recent years, many biosimilar agents that are hig......

Pelvic Ultrasound Parameters of Long-Acting Depot Formulation of Leuprorelin in the Treatment of Idiopathic Central Precocious Puberty in Girls

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Objective: The present study was designed to compare the changes in ovarian and uterine parameters in girls with idiopathic central precocious puberty......

Lactobacillus plantarum ZS62 Alleviates Alcohol-Induced Gastric Injury in Mice via an Anti-Oxidative Mechanism

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Aim: Gastric mucosal injury is a typical characteristic of gastric diseases. The prevalence of gastric mucosal injury caused by alcohol has been on th......

Clinical Application of Cytokines in Cancer Immunotherapy

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Cytokines are key components of the immune system and play pivotal roles in anticancer immune response. Cytokines as either therapeutic agents or targ......

Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Background: Rhubarb, as a traditional Chinese medicine, is the preferred drug for the treatment of stagnation and constipation in clinical practice. I......

Potential Mechanism of S. baicalensis on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Background: S. baicalensis, a traditional herb, has great potential in treating diseases associated with aberrant lipid metabolism, such as inflammati......

A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Purpose: Isatis indigotica (Ii) is a cruciferous herb that is widely distributed in China, and its roots and leaves have been used in two renowned ant......

Factors Associated with Benzodiazepines Prolonged-Term Use in Post-Stroke Subjective Sleep Disturbance: A Single-Centre Retrospective Study from China

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Purpose: To investigate the prevalence of short- and long-term benzodiazepine and z-drugs (BZD) for the treatment of post-stroke subjective sleep dist......

White Tip Silver Needle (Slightly Fermented White Tea) Flavonoids Help Prevent Aging via Antioxidative and Anti-Inflammatory Effects

期刊: DRUG DESIGN DEVELOPMENT AND THERAPY, 2021; 15 ()

Aim: White tip silver needle, a slightly fermented white tea, is abundant in flavonoids, and it has great significance in terms of D-galactose/lipopol......

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