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A novel rat tail disc degeneration model induced by static bending and compression

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2021; 4 (3)

Background A new rat tail intervertebral disc degeneration model was established to observe the morphologic and biologic changes of static bending and......

Animal models of stroke

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2021; 4 (3)

Stroke is a devastating disease with high morbidity and mortality. Animal models are indispensable tools that can mimic stroke processes and can be us......

Identification ACTA2 and KDR as key proteins for prognosis of PD-1/PD-L1 blockade therapy in melanoma

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2021; 4 (2)

Programmed cell death protein 1 (PD-1) /programmed cell death ligand 1 (PD-L1) blockade is an important therapeutic strategy for melanoma, despite its......

Microarray microRNA profiling of urinary exosomes in a 5XFAD mouse model of Alzheimer's disease

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2021; 4 (3)

Background Alzheimer's disease (AD) is an incurable and irreversible neurodegenerative disease, without a clear pathogenesis. Therefore, identificatio......

SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2021; 4 (1)

BackgroundCardiovascular diseases (CVDs) and diabetes mellitus (DM) are top two chronic comorbidities that increase the severity and mortality of COVI......

Summary of animal models of myelodysplastic syndrome

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2021; 4 (1)

Myelodysplastic syndrome (MDS) is a malignant tumor of the hematological system characterized by long-term, progressive refractory hemocytopenia. In a......

Generation and expression analysis of BAC humanized mice carrying HLA-DP401 haplotype

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2021; 4 (2)

Background Human leukocyte antigen (HLA)-DP is much less studied than other HLA class II antigens, that is, HLA-DR and HLA-DQ, etc. However, the accum......

Novel spontaneous myelodysplastic syndrome mouse model

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2021; 4 (2)

Background Myelodysplastic syndrome (MDS) is a group of disorders involving hemopoietic dysfunction leading to leukemia. Although recently progress ha......

A review of cystic fibrosis: Basic and clinical aspects

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2021; 4 (3)

Cystic fibrosis is an autosomal recessive disease caused by mutations of the gene encoding the cystic fibrosis transmembrane conductance regulator (CF......

Effects of long-term exposure to TDCPP in zebrafish (Danio rerio) - Alternations of hormone balance and gene transcriptions along hypothalamus-pituitary axes

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2022; 5 (3)

Background TDCPP is one of the major chemical of organophosphate flame retardants (OPFRs) that has been detected ubiquitously in both the environment ......

The effects of coloring therapy on patients with generalized anxiety disorder

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2022; 5 (6)

Generalized anxiety disorder (GAD) has harmful effects on physical and mental health and quality of life. Coloring therapy has been reported to have a......

Kunming mouse strain is less susceptible to elastase-induced abdominal aortic aneurysms

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2022; 5 (1)

Background Porcine pancreatic elastase (PPE) is successfully used to induce abdominal aortic aneurysm (AAA) in mice. However, differences between mous......

Circular RNAs in pulmonary hypertension: Emerging biological concepts and potential mechanism

期刊: ANIMAL MODELS AND EXPERIMENTAL MEDICINE, 2022; 5 (1)

Circular RNAs (circRNAs) are endogenous RNAs with a covalently closed single-stranded transcript. They are a novel class of genomic regulators that ar......

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