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Multimarker Panels for Detection of Early Stage Hepatocellular Carcinoma: A Prospective, Multicenter, Case-Control Study

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (4)

Hepatocellular carcinoma (HCC), the sixth most common cancer worldwide, has an incidence rate equal to mortality. Over 80% of HCC cases occur within a......

Hepatocyte TGF-beta Signaling Inhibiting WAT Browning to Promote NAFLD and Obesity Is Associated With Let-7b-5p

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (6)

Transforming growth factor beta (TGF-beta) signaling in hepatocytes promotes steatosis and body weight gain. However, processes that TGF-beta signalin......

Mid-upper arm circumference is associated with liver steatosis and fibrosis in patients with metabolic-associated fatty liver disease: A population based observational study

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (9)

Metabolic-associated fatty liver disease (MAFLD) is a series of liver diseases based on liver steatosis and metabolic disorders. Steatosis, as the cor......

Intratumoral Microbiome of Human Primary Liver Cancer

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (7)

Primary liver tumors (PLCs) and liver metastasis currently represent the leading cause of cancer-related deaths worldwide due to poor outcomes, high i......

Proteomics-based identification of the role of osteosarcoma amplified-9 in hepatocellular carcinoma recurrence

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (8)

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies; its recurrence is associated with high mortality and poor recurrence-free su......

Health-Related Quality of Life and Its Contributors According to a Preference-Based Generic Instrument in Cirrhosis

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (3)

It is essential to determine contributors around impairment in health-related quality of life (HRQoL) in patients with cirrhosis aiming at improving h......

Associations between six dietary habits and risk of hepatocellular carcinoma: A Mendelian randomization study

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (8)

Diet is reported to be associated with hepatocellular carcinoma (HCC), but whether there is a causal relationship remains unclear. This study aimed to......

A multi-analyte cell-free DNA-based blood test for early detection of hepatocellular carcinoma

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (7)

The limited performance of guideline-recommended abdominal ultrasound and serum alpha-fetoprotein (AFP) highlights the urgent, unmet need for new biom......

Co-regulation of hepatic steatosis by ferritinophagy and unsaturated fatty acid supply

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (10)

Both iron overload and iron deficiency have been reported in obesity and metabolic syndromes. Due to the presence of multiple intracellular iron pools......

Efficacy and safety of fenofibrate addition therapy in patients with cirrhotic primary biliary cholangitis with incomplete response to ursodeoxycholic acid

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (12)

Fenofibrate (FF) has shown potential benefits in patients with primary biliary cholangitis (PBC) who have an incomplete response to ursodeoxycholic ac......

Outcomes of subjects who are lean, overweight or obese with nonalcoholic fatty liver disease: A cohort study in China

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (12)

The ability to determine the prognosis of lean nonalcoholic fatty liver disease (NAFLD) is essential for decision making in clinical settings. Using a......

Loss of SLC46A1 decreases tumor iron content in hepatocellular carcinoma

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (10)

It is interesting that high iron is an independent inducer or cofactor of hepatocellular carcinoma (HCC) while the amount of iron is decreased in the ......

Prophylactic effect of tenofovir on viral reactivation in immunocompromised pregnant women living with hepatitis B virus

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (9)

The appropriate prophylaxis for hepatitis B virus reactivation (HBVr) during gestation for immunocompromised pregnant women has yet to be determined. ......

Dysregulation of global circular RNA abundance regulated by spliceosomes predicts prognosis in hepatocellular carcinoma

期刊: HEPATOLOGY COMMUNICATIONS, 2022; 6 (12)

CircRNAs have been reported to play crucial roles in tumor progression and recurrence, showing potential as biomarkers in cancer. However, the global ......

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