A Cereblon Modulator CC-885 Induces CRBN- and p97-Dependent PLK1 Degradation and Synergizes with Volasertib to Suppress Lung Cancer

Li, LF; Xue, WH; Shen, ZB; Liu, J; Hu, M; Cheng, ZY; Wang, YX; Chen, YL; Chang, H; Liu, YY; Liu, B; Zhao, J

Zhao, J (corresponding author), Zhengzhou Univ, Dept Pharm, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China.; Liu, B (corresponding author), Hubei Polytech Univ, Hubei Key Lab Kidney Dis Pathogenesis & Intervent, Sch Med, Huangshi 435003, Hubei, Peoples R China.

MOLECULAR THERAPY-ONCOLYTICS, 2020; 18 (): 215

Abstract

Therapeutic targeting of advanced or metastatic non-small-cell lung cancer (NSCLC) represents a major goal of clinical treatment. Polo-like kinase 1 (......

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