Bone marrow stromal cells induce an ALDH(+) stem cell-like phenotype and enhance therapy resistance in AML through a TGF-beta-p38-ALDH2 pathway

Yuan, B; El Dana, F; Ly, S; Yan, YQ; Ruvolo, V; Shpall, EJ; Konopleva, M; Andreeff, M; Battula, VL

Andreeff, M; Battula, VL (corresponding author), Univ Texas MD Anderson Canc Ctr, Sect Mol Hematol & Therapy, Dept Leukemia, Houston, TX 77030 USA.

PLOS ONE, 2020; 15 (11):

Abstract

The bone marrow microenvironment (BME) in acute myeloid leukemia (AML) consists of various cell types that support the growth of AML cells and protect......

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