Consequences of VHL Loss on Global DNA Methylome

Robinson, CM; Lefebvre, F; Poon, BP; Bousard, A; Fan, XJ; Lathrop, M; Tost, J; Kim, WY; Riazalhosseini, Y; Ohh, M

Ohh, M (reprint author), Univ Toronto, Dept Lab Med & Pathobiol, 661 Univ Ave,Room 1510, Toronto, ON M5G1M1, Canada.; Ohh, M (reprint author), Univ Toronto, Dept Biochem, 661 Univ Ave,Room 1510, Toronto, ON M5G1M1, Canada.

SCIENTIFIC REPORTS, 2018; 8 ():

Abstract

In clear-cell renal cell carcinoma (ccRCC), loss of von Hippel-Lindau (VHL) tumour suppressor gene and reduced oxygen tension promote stabilisation of......

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