Discovery of a benzimidazole series as the first highly potent and selective ACSL1 inhibitors

Hayashi, K; Kondo, N; Omori, N; Yoshimoto, R; Hato, M; Shigaki, S; Nagasawa, A; Ito, M; Okuno, T

Hayashi, K; Okuno, T (corresponding author), Shionogi Pharmaceut Res Ctr, Pharmaceut Res Div, 3-1-1 Futaba Cho, Toyonaka, Osaka 5610825, Japan.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021; 33 ():

Abstract

Long-chain acyl-CoA synthetase-1 (ACSL1), an enzyme that catalyzes the synthesis of long-chain acyl-CoA from the corresponding fatty acids, is believe......

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