New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

Chiarelli, LR; Mori, M; Beretta, G; Gelain, A; Pini, E; Sammartino, JC; Stelitano, G; Barlocco, D; Costantino, L; Lapillo, M; Poli, G; Caligiuri, I; Rizzolio, F; Bellinzoni, M; Tuccinardi, T; Villa, S; Meneghetti, F

Villa, S (reprint author), Univ Milan, Dept Pharmaceut Sci, Via L Mangiagalli 25, I-20133 Milan, Italy.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2019; 34 (1): 823

Abstract

Starting from the analysis of the hypothetical binding mode of our previous furan-based hit (I), we successfully achieved our objective to replace the......

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