KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS

Ambrogio, C; Kohler, J; Zhou, ZW; Wang, HY; Paranal, R; Li, JQ; Capelletti, M; Caffarra, C; Li, S; Lv, Q; Gondi, S; Hunter, JC; Lu, J; Chiarle, R; Santamaria, D; Westover, KD; Janne, PA

Ambrogio, C; Janne, PA (reprint author), Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA.; Westover, KD (reprint author), Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA.; Westover, KD (reprint author), Univ Texas So

CELL, 2018; 172 (4): 857

Abstract

The mechanism by which the wild-type KRAS allele imparts a growth inhibitory effect to oncogenic KRAS in various cancers, including lung adenocarcinom......

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