Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression

Colombo, S; de Sena-Tomas, C; George, V; Werdich, AA; Kapur, S; MacRae, CA; Targoff, KL

Targoff, KL (reprint author), Columbia Univ, Div Cardiol, Dept Pediat, Coll Phys & Surg, New York, NY 10032 USA.

DEVELOPMENT, 2018; 145 (3):

Abstract

NKX2-5 is the most commonly mutated gene associated with human congenital heart defects (CHDs), with a predilection for cardiac pole abnormalities. Th......

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