A Deep Learning Approach to Antibiotic Discovery

Stokes, JM; Yang, K; Swanson, K; Jin, WG; Cubillos-Ruiz, A; Donghia, NM; MacNair, CR; French, S; Carfrae, LA; Bloom-Ackerman, Z; Tran, VM; Chiappino-Pepe, A; Badran, AH; Andrews, IW; Chory, EJ; Church, GM; Brown, ED; Jaakkola, TS; Barzilay, R; Collins, JJ

Collins, JJ (corresponding author), MIT, Inst Med Engn & Sci, Synthet Biol Ctr, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.; Collins, JJ (corresponding author), Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.; Barzilay, R (corresponding author), MIT, Machine Learning Pharmaceut Discovery & Synth Con, 77 Massachusetts Ave, Cambridge, MA 02139 USA.; Barzilay, R (corresponding author), MIT, Comp Sci & Artificial Intelligence Lab, 77 Massachusetts Ave, Cambridge, MA 02139 USA.; Collins, JJ (corresponding author), Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.; Collins, JJ (corresponding author), Harvard MIT Program Hlth Sci & Technol, Cambridge, MA 02139 USA.; Barzilay, R; Collins, JJ (corresponding author), MIT, Abdul Latif Jameel Clin Machine Learning Hlth, 77 Massachusetts Ave, Cambridge, MA 02139 USA.

CELL, 2020; 180 (4): 688

Abstract

Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we traine......

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