Multi-Omics Profiling to Assess Signaling Changes upon VHL Restoration and Identify Putative VHL Substrates in Clear Cell Renal Cell Carcinoma Cell Lines

Wang, XC; Hu, J; Fang, YH; Fu, YB; Liu, B; Zhang, C; Feng, S; Lu, X

Zhang, C (通讯作者),Tongji Univ, Sch Life Sci & Technol, Shanghai Sunshine Rehabil Ctr, Fundamental Res Ctr,Shanghai YangZhi Rehabil Hosp, Shanghai 200092, Peoples R China.;Lu, X (通讯作者),Univ Notre Dame, Harper Canc Res Inst, Boler Parseghian Ctr Rare & Neglected Dis, Dept Biol Sci, Notre Dame, IN 46556 USA.;Feng, S (通讯作者),Westlake Univ, Key Lab Struct Biol Zhejiang Prov, Mass Spectrometry & Metabol Core Facil, Hangzhou 310024, Peoples R China.

CELLS, 2022; 11 (3):

Abstract

The inactivation of von Hippel-Lindau (VHL) is critical for clear cell renal cell carcinoma (ccRCC) and VHL syndrome. VHL loss leads to the stabilizat......

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