Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

Chiarelli, LR; Mori, M; Barlocco, D; Beretta, G; Gelain, A; Pini, E; Porcino, M; Mori, G; Stelitano, G; Costantino, L; Lapillo, M; Bonanni, D; Poli, G; Tuccinardi, T; Villa, S; Meneghetti, F

Villa, S (reprint author), Univ Milan, Dipartimento Sci Farmaceut, Via L Mangiagalli 25, I-20133 Milan, Italy.; Tuccinardi, T (reprint author), Univ Pisa, Dipartimento Farm, Via Bonanno 6, I-56126 Pisa, Italy.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018; 155 (): 754

Abstract

We report on the virtual screening, synthesis, and biological evaluation of new furan derivatives targeting Mycobacterium tuberculosis salicylate synt......

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