CIC protein instability contributes to tumorigenesis in glioblastoma

Bunda, S; Heir, P; Metcalf, J; Li, ASC; Agnihotri, S; Pusch, S; Yasin, M; Li, M; Burrell, K; Mansouri, S; Singh, O; Wilson, M; Alamsahebpour, A; Nejad, R; Choi, B; Kim, D; von Deimling, A; Zadeh, G; Aldape, K

Zadeh, G; Aldape, K (reprint author), Princess Margaret Canc Ctr, MacFeeters Hamilton Ctr Neurooncol Res, Toronto, ON M5G 2C1, Canada.; Zadeh, G (reprint author), Toronto Western Hosp, Div Neurosurg, Toronto, ON M5G 2C1, Canada.; Zadeh, G (reprint author)

NATURE COMMUNICATIONS, 2019; 10 ():

Abstract

Capicua (CIC) is a transcriptional repressor that counteracts activation of genes downstream of receptor tyrosine kinase (RTK)/Ras/ERK signaling. It i......

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