Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket

Sundriyal, S; Moniot, S; Mahmud, Z; Yao, S; Di Fruscia, P; Reynolds, CR; Dexter, DT; Sternberg, MJE; Lam, EWF; Steegborn, C; Fuchter, MJ

Fuchter, MJ (reprint author), Imperial Coll London, Dept Chem, London SW7 2AZ, England.

JOURNAL OF MEDICINAL CHEMISTRY, 2017; 60 (5): 1928

Abstract

Sirtuins (SIRTs) are NAD-dependent deacylases, known to be involved in a variety of pathophysiological processes and thus remain promising therapeutic......

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