Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors

Jiang, A; Liu, QF; Wang, RF; Wei, P; Dai, Y; Wang, X; Xu, YC; Ma, YC; Ai, J; Shen, JK; Ding, J; Xiong, B

Ai, J (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China.; Xu, YC (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Drug Design & Discove

MOLECULES, 2018; 23 (3):

Abstract

Fibroblast growth factor receptors (FGFRs), a subfamily of receptor tyrosine kinases, are aberrant in various cancer types, and considered to be promi......

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